antibody

Rabbit Polyclonal to Human PHAP1 / ANP32A

MBS240833

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal to Human PHAP1 / ANP32A

PHAP1 / ANP32A

Anti-PHAP1 / ANP32A Antibody (C-Terminus) IHC-plus; ANP32A; Hepatopoietin Cn; I1PP2A; LANP; HPPCn; PHAP1; PHAPI; MAPM; PP32; C15orf1; Mapmodulin; Human PHAP1; ANP32A

acidic leucine-rich nuclear phosphoprotein 32 family member A; Acidic leucine-rich nuclear phosphoprotein 32 family member A; acidic leucine-rich nuclear phosphoprotein 32 family member A; mapmodulin; hepatopoietin Cn; acidic nuclear phosphoprotein pp32; leucine-rich acidic nuclear protein; putative HLA-DR-associated protein I; inhibitor-1 of protein phosphatase-2A; cerebellar leucine rich acidic nuclear protein; putative human HLA class II associated protein I; potent heat-stable protein phosphatase 2A inhibitor I1PP2A; acidic (leucine-rich) nuclear phosphoprotein 32 family, member A; Acidic nuclear phosphoprotein pp32; pp32; Leucine-rich acidic nuclear protein; LANP; Mapmodulin; Potent heat-stable protein phosphatase 2A inhibitor I1PP2A; Putative HLA-DR-associated protein I; PHAPI

PHAP1

ANP32A

ANP32A; ANP32A; LANP; MAPM; PP32; HPPCn; PHAP1; PHAPI; I1PP2A; C15orf1; C15orf1; LANP; MAPM; PHAP1; pp32; LANP; PHAPI

AN32A_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

249

Synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I

Immunoaffinity Purified

PBS, 0.02% sodium azide.

1 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (10 ug/ml), WB (0.5 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I.

Immunogen: PHAP1 / ANP32A antibody was raised against synthetic peptide corresponding to amino acids at carboxy terminus of human PHAP I. Antigen Modification: C-Terminus

Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis.

5453880

NP_006296.1

NM_006305.3

P39687

28,585 Da

Gene Expression Pathway (105937); HuR Stabilizes MRNA Pathway (187216); Regulation Of MRNA Stability By Proteins That Bind AU-rich Elements Pathway (187211)

ANP32A: Implicated in a number of cellular processes, including proliferation, differentiation, caspase-dependent and caspase- independent apoptosis, suppression of transformation (tumor suppressor), inhibition of protein phosphatase 2A, regulation of mRNA trafficking and stability in association with ELAVL1, and inhibition of acetyltransferases as part of the INHAT (inhibitor of histone acetyltransferases) complex. Plays a role in E4F1- mediated transcriptional repression. Belongs to the ANP32 family. Protein type: Transcription, coactivator/corepressor; Nuclear receptor co-regulator. Chromosomal Location of Human Ortholog: 15q23. Cellular Component: nucleoplasm; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; nucleus. Molecular Function: protein binding. Biological Process: regulation of transcription, DNA-dependent; transcription, DNA-dependent; gene expression; nucleocytoplasmic transport

0.05 mg

495 USD