antibody

Goat Polyclonal to Human CAV1 / Caveolin 1

MBS240768

0.05 mg

495 USD

polyclonal

goat

nonconjugated

human, chimpanzee

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Goat Polyclonal to Human CAV1 / Caveolin 1

CAV1 / Caveolin 1

Anti-CAV1 / Caveolin 1 Antibody (Internal) IHC-plus; CAV1; Caveolin-1; CGL3; CAV; MSTP085; VIP21; BSCL3; Human CAV1; Caveolin 1

caveolin-1 isoform alpha; Caveolin-1; caveolin-1; cell growth-inhibiting protein 32; caveolin 1, caveolae protein, 22kDa

CAV1

CAV1; CAV1; CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085; CAV

CAV1_HUMAN

Polyclonal

Goat

Gibbon, Chimpanzee, Gorilla, Human, Monkey. Predicted Reactivity: Orangutan, Guinea pig (at least 90% immunogen sequence identity)

178

Human CAV1 / Caveolin. No cross-reactivity expected to Caveolin 2 and Caveolin 3

Immunoaffinity Purified

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

0.5 mg/ml

Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:32000), IHC-P (2.5 ug/ml), WB (0.3 - 1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Synthetic peptide C-DELSEKQVYDAH from an internal region of human CAV1 / Caveolin (NP_001744.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%); Orangutan, Guinea pig (92%).

Immunogen Type: Synthetic peptide. Immunogen: CAV1 / Caveolin 1 antibody was raised against synthetic peptide C-DELSEKQVYDAH from an internal region of human CAV1 / Caveolin (NP_001744.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Baboon, Monkey, Marmoset (100%); Orangutan, Guinea pig (92%); Mouse, Rat, Dog, Bat, Hamster, Rabbit, Horse (83%). Antigen Modification: Internal

Caveolin 1 (CAV1) is the main component of the caveolae plasma membranes found in most cell types. Caveolin 1 functions as a membrane adaptor to link integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 may also be a tumor suppressor gene and a negative regulator of the Ras-p42/44 MAP kinase cascade.

15451856

NP_001744.2

NM_001753.4

Q03135

17,023 Da

ALK1 Signaling Events Pathway (137968); Androgen Receptor Signaling Pathway (198806); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Basigin Interactions Pathway (106065); Canonical Wnt Signaling Pathway (138032); Cell Surface Interactions At The Vascular Wall Pathway (106062); Direct P53 Effectors Pathway (137939); Disease Pathway (530764); EGFR1 Signaling Pathway (198782)

The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase cascade. Caveolin 1 and caveolin 2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. Mutations in this gene have been associated with Berardinelli-Seip congenital lipodystrophy. Alternatively spliced transcripts encode alpha and beta isoforms of caveolin 1.[provided by RefSeq, Mar 2010]

Caveolin-1: May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Involved in the costimulatory signal essential for T-cell receptor (TCR)- mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin. Interacts with rotavirus A NSP4. Interacts (via the N- terminus) with DPP4; the interaction is direct. Interacts with CTNNB1, CDH1 and JUP. Interacts with BMX and BTK. Expressed in muscle and lung, less so in liver, brain and kidney. Belongs to the caveolin family. 2 isoforms of the human protein are produced by alternative initiation. Protein type: Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Adaptor/scaffold. Chromosomal Location of Human Ortholog: 7q31.1. Cellular Component: focal adhesion; protein complex; endoplasmic reticulum; integral to plasma membrane; basolateral plasma membrane; lipid particle; cell cortex; caveola; cilium; acrosomal membrane; lipid raft; Golgi membrane; early endosome membrane; perinuclear region of cytoplasm; apical plasma membrane; plasma membrane; cytoplasmic vesicle; intracellular; endosome. Molecular Function: identical protein binding; protein binding; enzyme binding; protease activator activity; cholesterol binding; patched binding; protein complex scaffold; nitric-oxide synthase binding; structural molecule activity; protein kinase binding; receptor binding. Biological Process: mammary gland involution; viral reproduction; negative regulation of epithelial cell differentiation; negative regulation of tyrosine phosphorylation of Stat5 protein; nitric oxide homeostasis; negative regulation of BMP signaling pathway; calcium ion homeostasis; protein localization; sequestering of lipid; regulation of the force of heart contraction by chemical signal; regulation of fatty acid metabolic process; negative regulation of protein binding; inactivation of MAPK activity; maintenance of cellular protein localization; regulation of smooth muscle contraction; skeletal muscle development; cytosolic calcium ion homeostasis; negative regulation of nitric-oxide synthase activity; cellular response to starvation; membrane depolarization; cholesterol homeostasis; response to estrogen stimulus; T cell costimulation; negative regulation of endothelial cell proliferation; negative regulation of protein ubiquitination; regulation of nitric-oxide synthase activity; response to progesterone stimulus; response to calcium ion; negative regulation of JAK-STAT cascade; leukocyte migration; lactation; vesicle organization and biogenesis; negative regulation of peptidyl-serine phosphorylation; negative regulation of transcription from RNA polymerase II promoter; negative regulation of pinocytosis; nitric oxide metabolic process; mammary gland development; calcium ion transport; negative regulation of cytokine and chemokine mediated signaling pathway; angiogenesis; vasculogenesis; protein homooligomerization; vasoconstriction; cholesterol transport; negative regulation of MAPKKK cascade; negative regulation of nitric oxide biosynthetic process; MAPKKK cascade; positive regulation of metalloenzyme activity; positive regulation of peptidyl-serine phosphorylation; regulation of peptidase activity; cellular calcium ion homeostasis; triacylglycerol metabolic process; regulation of blood coagulation; response to hypoxia; positive regulation of vasoconstriction; vascular endothelial growth factor receptor signaling pathway; blood coagulation. Disease: Lipodystrophy, Congenital Generalized, Type 3; Partial Lipodystrophy, Congenital Cataracts, And Neurodegeneration Syndrome; Pulmonary Hypertension, Primary, 3

0.05 mg

495 USD