Rabbit Polyclonal to Human ZIF268 / EGR1 | MyBioSource MBS240672 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human ZIF268 / EGR1

catalog :

MBS240672

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, chimpanzee

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240672

products type :

Antibody

products full name :

Rabbit Polyclonal to Human ZIF268 / EGR1

products short name :

ZIF268 / EGR1

products name syn :

Anti-ZIF268 / EGR1 Antibody (aa94-108) IHC-plus; EGR1; AT225; Early growth response 1; G0S30; KROX24; NGFIA; KROX-24; TIS8; ZIF-268; ZIF268; Zinc finger protein Krox-24; EGR-1; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Human ZIF268; EGR1

other names :

early growth response protein 1; Early growth response protein 1; early growth response protein 1; EGR-1; zinc finger protein 225; transcription factor ETR103; transcription factor Zif268; zinc finger protein Krox-24; nerve growth factor-induced protein A; early growth response 1; AT225; Nerve growth factor-induced protein A; NGFI-A; Transcription factor ETR103; Transcription factor Zif268; Zinc finger protein 225; Zinc finger protein Krox-24

products gene name :

ZIF268

products gene name syn :

EGR1

other gene names :

EGR1; EGR1; TIS8; AT225; G0S30; NGFI-A; ZNF225; KROX-24; ZIF-268; KROX24; ZNF225; EGR-1; NGFI-A

uniprot entry name :

EGR1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Chimpanzee, Human, Mouse

sequence length :

543

specificity :

Amino acids 94-108 of Human EGR-1.

purity :

Immunoaffinity Purified

form :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

concentration :

0.93 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:4000 - 1:16000), IHC-P (10 ug/ml), WB (1:500 - 1:3000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human EGR1.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ZIF268 / EGR1 antibody was raised against synthetic peptide from human EGR1. Antigen Modification: aa94-108

products description :

EGR-1 (also called Early Growth Response protein 1, Krox-24 protein, ZIF268, Nerve growth factor-induced protein A or NGFI-A, Transcription factor ETR103, and Zinc finger protein 225 or AT225) is a transcriptional regulator that recognizes and binds to the DNA sequence 5'-CGCCCCCGC-3' (EGR-site). EGR1 has been implicated in diverse roles in the regulation of cell growth, apoptosis, and differentiation.

ncbi gi num :

4503493

ncbi acc num :

NP_001955.1

ncbi gb acc num :

NM_001964.2

uniprot acc num :

P18146

ncbi mol weight :

57,507 Da

ncbi pathways :

BDNF Signaling Pathway (712093); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Cytokine Signaling In Immune System Pathway (366171); Downstream Signaling In Naive CD8+ T Cells Pathway (138018); ErbB1 Downstream Signaling Pathway (138057); Glucocorticoid Receptor Regulatory Network Pathway (138014); HTLV-I Infection Pathway (373901); HTLV-I Infection Pathway (373889); Immune System Pathway (106386); Insulin Signaling Pathway (198845)

ncbi summary :

The protein encoded by this gene belongs to the EGR family of C2H2-type zinc-finger proteins. It is a nuclear protein and functions as a transcriptional regulator. The products of target genes it activates are required for differentitation and mitogenesis. Studies suggest this is a cancer suppressor gene. [provided by RefSeq, Dec 2014]

uniprot summary :

EGR1: Transcriptional regulator. Recognizes and binds to the DNA sequence 5 -CGCCCCCGC-3 (EGR-site). Activates the transcription of target genes whose products are required for mitogenesis and differentiation. By growth factors. Belongs to the EGR C2H2-type zinc-finger protein family. Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 5q31.1. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: histone acetyltransferase binding; protein binding; DNA binding; sequence-specific DNA binding; metal ion binding; double-stranded DNA binding; transcription factor activity; transcription factor binding. Biological Process: response to nutrient levels; regulation of long-term neuronal synaptic plasticity; circadian rhythm; transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; response to amphetamine; negative regulation of transcription from RNA polymerase II promoter; response to cocaine; BMP signaling pathway; learning and/or memory; response to ethanol; cellular response to insulin stimulus; positive regulation of neuron apoptosis; response to glucose stimulus; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; response to electrical stimulus; regulation of protein sumoylation; T cell differentiation; negative regulation of apoptosis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage