Rabbit Polyclonal to Human CAMK2A / CaMKII Alpha | MyBioSource MBS240611 product information

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product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human CAMK2A / CaMKII Alpha

catalog :

MBS240611

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

product information

catalog number :

MBS240611

products type :

Antibody

products full name :

Rabbit Polyclonal to Human CAMK2A / CaMKII Alpha

products short name :

CAMK2A / CaMKII Alpha

products name syn :

Anti-CAMK2A / CaMKII Alpha Antibody (aa6-23) IHC-plus; CAMK2A; AlphaCaMKII; CaM-kinase II alpha chain; CaMK-II subunit alpha; CAMKA; CaM kinase II alpha; CaMK II alpha; CaMK-II alpha subunit; CaMKIINalpha; CaM kinase II alpha subunit; CaM kinase II subunit alpha; CaMKII alpha; CaMKIIalpha; KIAA0968; Human CAMK2A; CaMKII Alpha

other names :

calcium/calmodulin-dependent protein kinase type II subunit alpha isoform 1; Calcium/calmodulin-dependent protein kinase type II subunit alpha; calcium/calmodulin-dependent protein kinase type II subunit alpha; CaMKIINalpha; CaMK-II alpha subunit; caMK-II subunit alpha; CaM-kinase II alpha chain; CaM kinase II alpha subunit; caM kinase II subunit alpha; calcium/calmodulin-dependent protein kinase II alpha-B subunit; calcium/calmodulin-dependent protein kinase type II alpha chain; calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha; calcium/calmodulin-dependent protein kinase II alpha

products gene name :

CAMK2A

other gene names :

CAMK2A; CAMK2A; CAMKA; CAMKA; KIAA0968; CaM kinase II subunit alpha; CaMK-II subunit alpha

uniprot entry name :

KCC2A_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Dog, Human, Mouse, Orangutan, Rat

sequence length :

489

specificity :

Amino acids 6-23 of Human CaM Kinase II protein.

purity :

Purified

form :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

concentration :

1 mg/ml

storage stability :

Store vial at -20 degree C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:4000 - 1:20000), IF, IHC-P (2.5 ug/ml), WB (1:1000 - 1:3000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human CAMK2A.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: CAMK2A / CaMKII Alpha antibody was raised against synthetic peptide from human CAMK2A. Antigen Modification: aa6-23

products categories :

Family: Protein Kinase. Subfamily: CAMK2

products description :

CAMK2Alpha, together with the beta, delta, and gamma subunits, constititute the CAMK2 heteromultimeric holoenzyme serine/threonine kinase. CAMK2A has been implicated in learning, where it potentiates synaptic transmission by phosphorylating AMPA receptors. Variants are produced by alternative splicing.

ncbi gi num :

25952114

ncbi acc num :

NP_057065.2

ncbi gb acc num :

NM_015981.3

uniprot acc num :

Q9UQM7

ncbi mol weight :

55,320 Da

ncbi pathways :

Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway 161033!!Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Amphetamine Addiction Pathway 547607!!Amphetamine Addiction Pathway 550546!!BDNF Signaling Pathway 712093!!CREB Phosphorylation Through The Activation Of CaMKII Pathway 161040!!CREB Phosphorylation Through The Activation Of Ras Pathway 161036!!Ca2+ Pathway 1127532!!Calcium Regulation In The Cardiac Cell Pathway 198906

ncbi summary :

The product of this gene belongs to the serine/threonine protein kinases family, and to the Ca(2+)/calmodulin-dependent protein kinases subfamily. Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses. This calcium calmodulin-dependent protein kinase is composed of four different chains: alpha, beta, gamma, and delta. The alpha chain encoded by this gene is required for hippocampal long-term potentiation (LTP) and spatial learning. In addition to its calcium-calmodulin (CaM)-dependent activity, this protein can undergo autophosphorylation, resulting in CaM-independent activity. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Nov 2008]

size :

0.05 mg

price :

495 USD