Rabbit Polyclonal to Human MAD2L1 / MAD2 | MyBioSource MBS240551 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human MAD2L1 / MAD2

catalog :

MBS240551

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240551

products type :

Antibody

products full name :

Rabbit Polyclonal to Human MAD2L1 / MAD2

products short name :

MAD2L1 / MAD2

products name syn :

Anti-MAD2L1 / MAD2 Antibody (aa3-13) IHC-plus; MAD2L1; HSMAD2; MAD2; MAD2-like protein 1; Human MAD2L1; MAD2

other names :

mitotic spindle assembly checkpoint protein MAD2A; Mitotic spindle assembly checkpoint protein MAD2A; mitotic spindle assembly checkpoint protein MAD2A; MAD2-like protein 1; mitotic arrest deficient 2-like protein 1; mitotic arrest deficient, yeast, homolog-like 1; MAD2 (mitotic arrest deficient, yeast, homolog)-like 1; MAD2 mitotic arrest deficient-like 1 (yeast); Mitotic arrest deficient 2-like protein 1; MAD2-like protein 1

products gene name :

MAD2L1

products gene name syn :

MAD2

other gene names :

MAD2L1; MAD2L1; MAD2; HSMAD2; MAD2; HsMAD2; MAD2-like protein 1

uniprot entry name :

MD2L1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

205

specificity :

Amino acid residues 3-13 of Human MAD2L1 protein.

purity :

Immunoaffinity Purified

form :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

concentration :

1 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:2000 - 1:10000), IF, IHC-P (2.5 ug/ml), WB (1:500 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human MAD2L1.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: MAD2L1 / MAD2 antibody was raised against synthetic peptide from human MAD2L1. Antigen Modification: aa3-13

ncbi gi num :

4505067

ncbi acc num :

NP_002349.1

ncbi gb acc num :

NM_002358.3

uniprot acc num :

Q13257

ncbi mol weight :

10,335 Da

ncbi pathways :

APC-Cdc20 Mediated Degradation Of Nek2A Pathway (1127551); APC/C-mediated Degradation Of Cell Cycle Proteins Pathway (105825); APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105831); APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway (1127549); Activation Of APC/C And APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway (105829); Amplification Of Signal From Unattached Kinetochores Via A MAD2 Inhibitory Signal Pathway (105761); Amplification Of Signal From The Kinetochores Pathway (105760); Cdc20:Phospho-APC/C Mediated Degradation Of Cyclin A Pathway (1127550); Cell Cycle Pathway (530733); Cell Cycle Checkpoints Pathway (105739)

ncbi summary :

MAD2L1 is a component of the mitotic spindle assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. MAD2L1 is related to the MAD2L2 gene located on chromosome 1. A MAD2 pseudogene has been mapped to chromosome 14. [provided by RefSeq, Jul 2008]

uniprot summary :

MAD2L1: required for the mitotic checkpoint which monitors the process of kinetochore-spindle attachment and delays the onset of anaphase when this process is not complete. Inhibits the activity of the anaphase promoting complex by sequestering CDC20 until all chromosomes are aligned at the metaphase plate. Interacts with Cdc20, MAD2L1BP and with ADAM17/TACE. Protein type: Cell cycle regulation. Chromosomal Location of Human Ortholog: 4q27. Cellular Component: kinetochore; spindle pole; perinuclear region of cytoplasm; nuclear pore; nucleus; cytosol. Molecular Function: identical protein binding; protein binding; protein homodimerization activity. Biological Process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; mitotic sister chromatid segregation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle checkpoint; mitotic cell cycle spindle assembly checkpoint; negative regulation of mitotic cell cycle; mitotic cell cycle; negative regulation of protein catabolic process; negative regulation of apoptosis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage