Rabbit Polyclonal to Human NF2 / Merlin | MyBioSource MBS240545 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human NF2 / Merlin

catalog :

MBS240545

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunoprecipitation, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240545

products type :

Antibody

products full name :

Rabbit Polyclonal to Human NF2 / Merlin

products short name :

NF2 / Merlin

products name syn :

Anti-NF2 / Merlin Antibody (phospho-Ser518) IHC-plus; NF2; ACN; BANF; Moesin-ezrin-radixin like; Neurofibromin 2 (merlin); Neurofibromin-2; SCH; Merlin; Schwannomerlin; Schwannomin; Human NF2; Merlin

other names :

merlin isoform 1; Merlin; merlin; schwannomin; schwannomerlin; neurofibromin-2; moesin-ezrin-radixin like; moesin-ezrin-radixin-like protein; moesin-ezrin-radizin-like protein; neurofibromin 2 (bilateral acoustic neuroma); neurofibromin 2 (merlin); Moesin-ezrin-radixin-like protein; Neurofibromin-2; Schwannomerlin; Schwannomin

products gene name :

NF2

other gene names :

NF2; NF2; ACN; SCH; BANF; SCH

uniprot entry name :

MERL_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse

sequence length :

595

specificity :

Human NF2 (Merlin) phospho-peptide corresponding to a region of the human protein surrounding S518 and conjugated to Keyhole Limpet Hemocyanin (KLH).

purity :

Immunoaffinity Purified

form :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

concentration :

1 mg/ml

storage stability :

Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)

app notes :

ELISA, IHC-P (2.5 ug/ml), IP, WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human

other info2 :

Antigen Modification: pSer518

products description :

Mutations linked to neurofibromatosis type 2 led to the identification of NF2. NF2 encodes a protein related to the cytoskeletal components moesin, ezrin, and radixin, and was thus named merlin.

ncbi gi num :

4557795

ncbi acc num :

NP_000259.1

ncbi gb acc num :

NM_000268.3

uniprot acc num :

P35240

ncbi mol weight :

24,515 Da

ncbi pathways :

ErbB2/ErbB3 Signaling Events Pathway (137955); Hippo Signaling Pathway (1084759); Hippo Signaling Pathway (1108222); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

ncbi summary :

This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that are thought to link cytoskeletal components with proteins in the cell membrane. This gene product has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. This gene is expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. Two predominant isoforms and a number of minor isoforms are produced by alternatively spliced transcripts. [provided by RefSeq, Jul 2008]

uniprot summary :

Merlin: a moesin-ezrin-radizin-like protein. Interacts with cell-surface proteins, proteins involved in cytoskeletal dynamics and proteins involved in regulating ion transport. Expressed at high levels during embryonic development; in adults, significant expression is found in Schwann cells, meningeal cells, lens and nerve. Mutations are associated with neurofibromatosis type II. Two predominant isoforms and eight minor isoforms are produced by alternatively spliced transcripts. Protein type: Motility/polarity/chemotaxis; Cytoskeletal; Tumor suppressor. Chromosomal Location of Human Ortholog: 22q12.2. Cellular Component: filopodium membrane; cortical actin cytoskeleton; early endosome; adherens junction; cytoskeleton; extrinsic to membrane; membrane; lamellipodium; perinuclear region of cytoplasm; apical part of cell; cytoplasm; plasma membrane; nucleolus; nucleus; cleavage furrow. Molecular Function: protein binding; actin binding. Biological Process: intercellular junction assembly and maintenance; negative regulation of MAPKKK cascade; hippocampus development; regulation of protein stability; negative regulation of tyrosine phosphorylation of Stat5 protein; negative regulation of cell-matrix adhesion; odontogenesis of dentine-containing teeth; Schwann cell proliferation; negative regulation of cell proliferation; mesoderm formation; negative regulation of DNA replication; positive regulation of stress fiber formation; negative regulation of tyrosine phosphorylation of Stat3 protein; ectoderm development; negative regulation of protein kinase activity; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; positive regulation of cell differentiation; negative regulation of JAK-STAT cascade; negative regulation of cell migration. Disease: Meningioma, Familial, Susceptibility To; Neurofibromatosis, Type Ii; Schwannomatosis 1

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage