catalog number :
MBS240544
products full name :
Rabbit Polyclonal to Human NFKB1
products short name :
NFKB1
products name syn :
Anti-NFKB1 Antibody (N-Terminus) IHC-plus; NFKB1; Ebp- 1; EBP-1; NF-KappaB p50; NFkappaB; NFKB-p50; KBF1; NF-kappa-B; NF-kappaB; NF-kB1; NFKB-p105; p105; p50; DNA binding factor KBF1; DNA-binding factor KBF1; NF-kappabeta; Human NFKB1
other names :
nuclear factor NF-kappa-B p105 subunit isoform 1; Nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p105 subunit; NF-kappabeta; DNA binding factor KBF1; DNA-binding factor KBF1; nuclear factor NF-kappa-B p50 subunit; nuclear factor kappa-B DNA binding subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; DNA-binding factor KBF1; EBP-1; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1Nuclear factor NF-kappa-B p50 subunit
products gene name :
NFKB1
other gene names :
NFKB1; NFKB1; p50; KBF1; p105; EBP-1; NF-kB1; NFKB-p50; NFkappaB; NF-kappaB; NFKB-p105; NF-kappa-B
uniprot entry name :
NFKB1_HUMAN
specificity :
Human NFkB p105 peptide corresponding to a region near the N-terminus of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
purity :
Delipidated and defibrinated
form :
Contains 0.01% sodium azide
storage stability :
Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.
tested application :
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
app notes :
ELISA, IF, IHC-P (1:500), IP, WB. Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.
other info1 :
Target Species: Human
other info2 :
Antigen Modification: N-Terminus
products categories :
Family: Apoptosis
ncbi acc num :
NP_003989.2
ncbi gb acc num :
NM_003998.3
ncbi mol weight :
85,520 Da
ncbi pathways :
AGE/RAGE Pathway 698754!!Activated TLR4 Signalling Pathway 106400!!Activation Of NF-kappaB In B Cells Pathway 576251!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Adaptive Immune System Pathway 366160!!Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Alternative NF-kappaB Pathway 138004!!Amoebiasis Pathway 167324
ncbi summary :
This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]