product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Polyclonal to Human PNKP
catalog :
MBS240533
quantity :
0.05 mg
price :
495 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, chimpanzee
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay
more info or order :
product information
catalog number :
MBS240533
products type :
Antibody
products full name :
Rabbit Polyclonal to Human PNKP
products short name :
PNKP
products name syn :
Anti-PNKP Antibody (Internal) IHC-plus; PNKP; EIEE10; DNA 5-kinase/3-phosphatase; PNK; MCSZ; Human PNKP
other names :
bifunctional polynucleotide phosphatase/kinase; Bifunctional polynucleotide phosphatase/kinase; bifunctional polynucleotide phosphatase/kinase; DNA 5'-kinase/3'-phosphatase; Homo sapiens polynucleotide kinase 3'-phosphatase (PNKP); polynucleotide kinase 3'-phosphatase; DNA 5'-kinase/3'-phosphatase; Polynucleotide kinase-3'-phosphataseIncluding the following 2 domains:Polynucleotide 3'-phosphatase (EC:3.1.3.32)Alternative name(s):2'(3')-polynucleotidase
products gene name :
PNKP
other gene names :
PNKP; PNKP; PNK; MCSZ; EIEE10
uniprot entry name :
PNKP_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Chimpanzee, Human
sequence length :
521
specificity :
An internal region of human PNK protein.
purity :
Immunoaffinity Purified
form :
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
concentration :
1 mg/ml
storage stability :
Long term: -20 degree C; Short term: -20 degree C
tested application :
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
app notes :
ELISA (1:3000 - 1:12000), IF, IHC-P (5 ug/ml), WB (1:300 - 1:1500). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide from human PNKP.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: PNKP antibody was raised against synthetic peptide from human PNKP. Antigen Modification: Internal
ncbi gi num :
31543419
ncbi acc num :
NP_009185.2
ncbi gb acc num :
NM_007254.3
uniprot acc num :
Q96T60
ncbi mol weight :
53,004 Da
ncbi summary :
This locus represents a gene involved in DNA repair. In response to ionizing radiation or oxidative damage, the protein encoded by this locus catalyzes 5' phosphorylation and 3' dephosphorylation of nucleic acids. Mutations at this locus have been associated with microcephaly, seizures, and developmental delay.[provided by RefSeq, Sep 2010]
uniprot summary :
Pnk1: polynucleotide kinase 3 -phosphatase. May be involved in double-strand break repair by non-homologous end joining. Required for normal response to DNA damage by gamma-radiation or camptothecin in S. pombe. Protein type: Kinase, other; EC 3.1.3.32; EC 2.7.1.78; DNA-binding; Phosphatase (non-protein). Chromosomal Location of Human Ortholog: 19q13.3-q13.4. Cellular Component: nucleoplasm; membrane; nucleolus; nucleus. Molecular Function: protein binding; ATP-dependent polydeoxyribonucleotide 5 -hydroxyl-kinase activity; polynucleotide 3 -phosphatase activity; purine nucleotide binding; endonuclease activity; double-stranded DNA binding; damaged DNA binding; nucleotide kinase activity; ATP binding. Biological Process: response to radiation; dephosphorylation; DNA damage response, detection of DNA damage; nucleotide-excision repair, DNA damage removal; response to oxidative stress; DNA repair; DNA-dependent DNA replication; nucleotide phosphorylation. Disease: Microcephaly, Seizures, And Developmental Delay; Ataxia-oculomotor Apraxia 4
size1 :
0.05 mg
price1 :
495 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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