antibody

Rabbit Polyclonal to Human PPP1R13L / RAI / IASPP

MBS240529

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Human PPP1R13L / RAI / IASPP

PPP1R13L / RAI / IASPP

Anti-PPP1R13L / RAI / IASPP Antibody (aa780-797) IHC-plus; PPP1R13L; IASPP; Inhibitor of ASPP protein; NFkB-interacting protein 1; NKIP1; RAI4; RAI; Retinoic acid induced 4; NFkB interacting protein 1; PPP1R13BL; Protein iASPP; RelA-associated inhibitor; PPP1R13B-like protein; Human PPP1R13L; RAI; IASPP

relA-associated inhibitor; RelA-associated inhibitor; relA-associated inhibitor; protein iASPP; PPP1R13B-like protein; retinoic acid induced 4; inhibitor of ASPP protein; NFkB interacting protein 1; NFkB-interacting protein 1; inhibitor of apoptosis stimulating protein of p53; protein phosphatase 1, regulatory (inhibitor) subunit 13 like; protein phosphatase 1, regulatory subunit 13 like; Inhibitor of ASPP protein; Protein iASPP; NFkB-interacting protein 1; PPP1R13B-like protein

PPP1R13L

RAI; IASPP

PPP1R13L; PPP1R13L; RAI; RAI4; IASPP; NKIP1; IASPP; NKIP1; PPP1R13BL; RAI; Protein iASPP

IASPP_HUMAN

Polyclonal

Rabbit

Human

828

Amino acids 780-797 of human iASPP (isoform 1) protein.

Immunoaffinity Purified

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

1 mg/ml

Store vial at -20 degree C prior to opening. Dilute only prior to immediate use. For extended storage aliquot contents and freeze at -20 degree C or below. Avoid cycles of freezing and thawing.

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

ELISA (1:40000 - 1:160000), IF, IHC-P (2.5 ug/ml), WB (1:1000 - 1:5000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Synthetic peptide from human PPP1R13L / IASPP.

Immunogen Type: Synthetic peptide. Immunogen: PPP1R13L / RAI / IASPP antibody was raised against synthetic peptide from human PPP1R13L / IASPP. Antigen Modification: aa780-797

63003907

NP_006654.2

NM_006663.3

Q8WUF5

89,091 Da

Integrated Pancreatic Cancer Pathway (711360); TNF-alpha/NF-kB Signaling Pathway (198884); P53 Pathway (138067)

IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]

PPP1R13L: an oncoprotein that interacts with and inhibits NF-kappaB, Sp1 and p53. Plays a central role in regulation of apoptosis and transcription. May inhibit p53 by preventing its association with ASPP1 or ASPP2, thereby suppressing the subsequent activation of apoptosis. Required for neuronal survival after axonal injury. Two alternatively spliced isoforms have been described. Isoform 1 is preferrentially found in the cytoplasm; isoform 2 is nuclear. Protein type: Phosphatase, regulatory subunit; Apoptosis; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: intercellular bridge; cytoplasm; cell junction; nucleus. Molecular Function: identical protein binding; protein binding; transcription factor binding; transcription corepressor activity. Biological Process: transcription, DNA-dependent; apoptosis; multicellular organism growth; negative regulation of transcription from RNA polymerase II promoter; multicellular organismal homeostasis; embryonic camera-type eye development; post-embryonic development; cardiac muscle contraction; hair cycle

0.05 mg

495 USD