Rabbit Polyclonal to Mouse PPARD / PPAR Delta | MyBioSource MBS240483 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Mouse PPARD / PPAR Delta

catalog :

MBS240483

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, enzyme immunoassay

product information

catalog number :

MBS240483

products type :

Antibody

products full name :

Rabbit Polyclonal to Mouse PPARD / PPAR Delta

products short name :

PPARD / PPAR Delta

products name syn :

Anti-PPARD / PPAR Delta Antibody (Internal) IHC-plus; PPARD; FAAR; NUCI; PPAR-beta; PPAR-delta; NR1C2; NUC1; NUCII; Nuclear hormone receptor 1; PPARB; PPAR Delta; Mouse PPARD; PPAR Delta

other names :

peroxisome proliferator-activated receptor delta isoform 1; Peroxisome proliferator-activated receptor delta; peroxisome proliferator-activated receptor delta; PPAR-beta; PPAR-delta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; peroxisome proliferator-activated receptor delta; NUCI; Nuclear hormone receptor 1; NUC1; Nuclear receptor subfamily 1 group C member 2; Peroxisome proliferator-activated receptor beta; PPAR-beta

products gene name :

PPARD

other gene names :

PPARD; PPARD; FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB; NR1C2; PPARB; PPAR-delta; NUC1; PPAR-beta

uniprot entry name :

PPARD_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human, Mouse, Rat

sequence length :

441

specificity :

Amino acids 1 -14 of mouse PPAR delta.

purity :

Immunoaffinity Purified

form :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

concentration :

1 mg/ml

storage stability :

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

app notes :

ELISA (1:2000 - 1:8000), IHC-P (2.5 ug/ml), WB (1:500 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.

other info1 :

Target Species: Mouse. Immunogen Description: Synthetic peptide from mouse PPARD.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: PPARD / PPAR Delta antibody was raised against synthetic peptide from mouse PPARD. Antigen Modification: Internal

products categories :

Family: NHR. Subfamily: NR1 Thyroid hormone-like

products description :

Peroxisome proliferator-activated receptor beta/delta (PPAR beta/delta), a NR1 Thyroid Hormone-Like Receptor, is involved in the regulation of acyl-CoA synthetase 2 expression, lipid metabolism, embryo development, implantation, decidualization, and bone formation. PPAR beta/delta has been identified as a negative target of the APC gene and has been linked to colon cancer.

ncbi gi num :

5453940

ncbi acc num :

NP_006229.1

ncbi gb acc num :

NM_006238.4

uniprot acc num :

Q03181

ncbi mol weight :

38,855 Da

ncbi pathways :

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adipogenesis Pathway (198832); Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Import Of Palmitoyl-CoA Into The Mitochondrial Matrix Pathway (106108); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976)

ncbi summary :

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

uniprot summary :

PPAR-delta: Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma-linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. Belongs to the nuclear hormone receptor family. NR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Nuclear receptor; DNA-binding. Chromosomal Location of Human Ortholog: 6p21.2. Cellular Component: nucleoplasm; nucleus. Molecular Function: NF-kappaB binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; transcription coactivator activity; steroid hormone receptor activity; drug binding; transcription factor activity; lipid binding. Biological Process: proteoglycan metabolic process; wound healing; negative regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-dependent; negative regulation of collagen biosynthetic process; heart development; positive regulation of epidermis development; decidualization; negative regulation of transcription from RNA polymerase II promoter; glucose transport; negative regulation of smooth muscle cell migration; positive regulation of vasodilation; vitamin A metabolic process; response to vitamin A; positive regulation of cell proliferation; response to glucose stimulus; axon ensheathment; cell differentiation; negative regulation of epithelial cell proliferation; cholesterol metabolic process; transcription initiation from RNA polymerase II promoter; generation of precursor metabolites and energy; intracellular receptor-mediated signaling pathway; positive regulation of insulin secretion; glucose metabolic process; keratinocyte proliferation; fatty acid catabolic process; keratinocyte migration; cell-substrate adhesion; phospholipid biosynthetic process; regulation of transcription from RNA polymerase II promoter; positive regulation of phosphoinositide 3-kinase cascade; cell proliferation; fatty acid beta-oxidation; negative regulation of inflammatory response; mRNA transcription; positive regulation of fat cell differentiation; gene expression; steroid hormone mediated signaling; response to activity; negative regulation of cell growth; lipid metabolic process; negative regulation of transcription, DNA-dependent; embryo implantation; fatty acid transport; negative regulation of apoptosis

size1 :

0.05 mg

price1 :

495 USD