antibody

Rabbit Polyclonal to Mouse PPAR Alpha

MBS240472

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat, dog, cow

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Mouse PPAR Alpha

PPAR Alpha

Anti-PPAR Alpha Antibody (N-Terminus) IHC-plus; PPAR Alpha; PPARalpha; PPAR-alpha; NR1C1; HPPAR; PPAR; Mouse PPAR Alpha

peroxisome proliferator-activated receptor alpha; Peroxisome proliferator-activated receptor alpha; peroxisome proliferator-activated receptor alpha; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; peroxisome proliferator-activated receptor alpha; Nuclear receptor subfamily 1 group C member 1

PPARA

PPARA; PPARA; PPAR; NR1C1; hPPAR; PPARalpha; NR1C1; PPAR; PPAR-alpha

PPARA_HUMAN

Polyclonal

Rabbit

Boar, Bovine, Dog, Hamster, Human, Mouse, Rat

468

Amino acids 1 to 18 of mouse PPAR alpha.

Immunoaffinity Purified

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

1 mg/ml

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:8000 - 1:32000), IHC-P (20 ug/ml), WB (1:500 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.

Target Species: Mouse. Immunogen Description: Synthetic peptide from mouse PPARA / PPAR.

Immunogen Type: Synthetic peptide. Immunogen: PPAR Alpha antibody was raised against synthetic peptide from mouse PPARA / PPAR. Antigen Modification: N-Terminus

Family: NHR. Subfamily: NR1 Thyroid hormone-like

Peroxisome Proliferator-Activated Receptor Alpha (PPAR alpha), a NR1 Thyroid Hormone-Like Receptor, is involved in the regulation of the hepatic response to peroxisomal proliferators, lipid metabolism, and inflammation response. PPAR Alpha binds to direct repeat 1 (DR1) hormone response elements as a heterodimer with the retinoic X receptor (RXR) and is activated by RXR ligands, fatty acids, peroxisome proliferators, and hypolipidemic fibrates including bezafibrate and clofibrate.

7549811

NP_005027.2

NM_005036.4

Q07869

18,942 Da

Activation Of Gene Expression By SREBF (SREBP) Pathway (685552); Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Circadian Clock Pathway (187173); Developmental Biology Pathway (477129); Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937)

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008]

PPAR-alpha: Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. Belongs to the nuclear hormone receptor family. NR1 subfamily. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 22q13.31. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein domain specific binding; ligand-dependent nuclear receptor activity; NFAT protein binding; zinc ion binding; drug binding; phosphatase binding; protein binding; DNA binding; ubiquitin conjugating enzyme binding; sequence-specific DNA binding; protein complex binding; steroid hormone receptor activity; lipid binding; transcription factor activity. Biological Process: circadian rhythm; epidermis development; wound healing; heart development; positive regulation of transcription, DNA-dependent; behavioral response to nicotine; cellular lipid metabolic process; negative regulation of transcription from RNA polymerase II promoter; fatty acid metabolic process; negative regulation of appetite; response to insulin stimulus; positive regulation of gluconeogenesis; negative regulation of blood pressure; circadian regulation of gene expression; negative regulation of protein binding; negative regulation of glycolysis; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; lipoprotein metabolic process; regulation of circadian rhythm; positive regulation of fatty acid beta-oxidation; positive regulation of fatty acid oxidation; response to hypoxia; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; lipid metabolic process; fatty acid transport

0.05 mg

495 USD