product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Polyclonal to Human CASP6 / Caspase 6
catalog :
MBS240453
quantity :
0.05 mg
price :
495 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry
more info or order :
product information
catalog number :
MBS240453
products type :
Antibody
products full name :
Rabbit Polyclonal to Human CASP6 / Caspase 6
products short name :
CASP6 / Caspase 6
products name syn :
Anti-CASP6 / Caspase 6 Antibody (Internal) IHC-plus; CASP6; Apoptotic protease Mch-2; Caspase 6; CASP-6; Caspase-6; Mch-2; MCH2; Human CASP6; Caspase 6
other names :
caspase-6 isoform alpha preproprotein; Caspase-6; caspase-6; apoptotic protease MCH-2; caspase 6, apoptosis-related cysteine protease; caspase 6, apoptosis-related cysteine peptidase; Apoptotic protease Mch-2Cleaved into the following 2 chains:Caspase-6 subunit p18; Caspase-6 subunit p11
products gene name :
CASP6
other gene names :
CASP6; CASP6; MCH2; MCH2; CASP-6
uniprot entry name :
CASP6_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human
sequence length :
293
specificity :
15 amino acid peptide from near the center of human Caspase-6
purity :
Immunoaffinity Purified
form :
PBS, 0.02% sodium azide.
concentration :
1 mg/ml
storage stability :
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
tested application :
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC), Western Blot (WB)
app notes :
ICC, IHC-P (2.5 ug/ml), WB (1 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.
other info1 :
Target Species: Human. Non Reactive Species: Mouse, Rat. Immunogen Description: Synthetic peptide from human CASP6 / Caspase 6.
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: CASP6 / Caspase 6 antibody was raised against synthetic peptide from human CASP6 / Caspase 6. Antigen Modification: Internal
products categories :
Family: Protease. Subfamily: Cysteine C14
products description :
Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens.
ncbi gi num :
14916483
ncbi acc num :
NP_001217.2
ncbi gb acc num :
NM_001226.3
uniprot acc num :
P55212
ncbi mol weight :
22,574 Da
ncbi pathways :
Apoptosis Pathway (198797); Apoptosis Pathway (83060); Apoptosis Pathway (470); Apoptosis Pathway (105648); Apoptosis Modulation And Signaling Pathway (198822); Apoptosis Modulation By HSP70 Pathway (198877); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Breakdown Of The Nuclear Lamina Pathway (105681); C-MYB Transcription Factor Network Pathway (138073)
ncbi summary :
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
uniprot summary :
CASP6: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. Activation is suppressed by phosphorylation at Ser-257. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Apoptosis; Protease; EC 3.4.22.59. Chromosomal Location of Human Ortholog: 4q25. Cellular Component: nucleoplasm; cytoplasm; cytosol. Molecular Function: identical protein binding; protein binding; cysteine-type endopeptidase activity; cysteine-type peptidase activity. Biological Process: epithelial cell differentiation; apoptosis; proteolysis; cell structure disassembly during apoptosis
size1 :
0.05 mg
price1 :
495 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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