This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Goat Polyclonal to Human LRP6
catalog :
MBS240429
quantity :
0.05 mg
price :
495 USD
clonality :
polyclonal
host :
goat
conjugate :
nonconjugated
reactivity :
human, rat, dog, cow
application :
immunohistochemistry, enzyme immunoassay
product information
catalog number :
MBS240429
products type :
Antibody
products full name :
Goat Polyclonal to Human LRP6
products short name :
LRP6
products name syn :
Anti-LRP6 Antibody (Internal) IHC-plus; LRP6; ADCAD2; LRP-6; Human LRP6
other names :
low-density lipoprotein receptor-related protein 6; Low-density lipoprotein receptor-related protein 6; low-density lipoprotein receptor-related protein 6; LRP-6; low density lipoprotein receptor-related protein 6
products gene name :
LRP6
other gene names :
LRP6; LRP6; ADCAD2; LRP-6
uniprot entry name :
LRP6_HUMAN
clonality :
Polyclonal
host :
Goat
reactivity :
Gibbon, Dog, Gorilla, Hamster, Horse, Human, Monkey, Pig, Rabbit, Rat. Predicted Reactivity: Mouse, Bat, Bovine (at least 90% immunogen sequence identity)
sequence length :
1613
specificity :
Human LRP6. This antibody is expected to recognise an epitope corresponding to aa 1546-1560 of human LRP6 protein.
purity :
Immunoaffinity Purified
form :
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
concentration :
0.5 mg/ml
storage stability :
Store at -20 degree C. Minimize freezing and thawing.
tested application :
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
app notes :
ELISA (1:64000), IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibod.
other info1 :
Target Species: Human. Immunogen Description: Synthetic peptide CMTSVATAKGYTSDL from an internal region of human LRP6 (NP_002327.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Hamster, Panda, Dog, Horse, Rabbit, Pig (100%); Mouse, Elephant, Bovine, Bat (93%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: LRP6 antibody was raised against synthetic peptide CMTSVATAKGYTSDL from an internal region of human LRP6 (NP_002327.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Hamster, Panda, Dog, Horse, Rabbit, Pig (100%); Mouse, Elephant, Bovine, Bat (93%). Antigen Modification: Internal
products description :
Low Density Lipoprotein Receptor-Related Protein 6 (LRP6) is a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. LRP6 functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade.
ncbi gi num :
148727288
ncbi acc num :
NP_002327.2
ncbi gb acc num :
NM_002336.2
uniprot acc num :
O75581
ncbi mol weight :
180,429 Da
ncbi pathways :
Canonical Wnt Signaling Pathway 138032!!Disease Pathway 530764!!MicroRNAs In Cardiomyocyte Hypertrophy Pathway 198784!!Presenilin Action In Notch And Wnt Signaling Pathway 137914!!RNF Mutants Show Enhanced WNT Signaling And Proliferation Pathway 1127632!!Signal Transduction Pathway 477114!!Signaling By WNT In Cancer Pathway 1127614!!Signaling By Wnt Pathway 106510!!TCF Dependent Signaling In Response To WNT Pathway 1127516!!Wnt Signaling Pathway NetPath 198799
ncbi summary :
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
size :
0.05 mg
price :
495 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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