antibody

Rabbit Polyclonal to Human E2F1

MBS240406

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, chimpanzee

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Human E2F1

E2F1

Anti-E2F1 Antibody (phospho-Ser364) IHC-plus; E2F1; E2F transcription factor 1; PRB-binding protein E2F-1; RBAP-1; RBBP3; RBBP-3; Transcription factor E2F1; RBAP1; E2F-1; PBR3; Human E2F1

transcription factor E2F1; Transcription factor E2F1; transcription factor E2F1; PBR3; RBAP-1; RBBP-3; PRB-binding protein E2F-1; retinoblastoma-binding protein 3; retinoblastoma-associated protein 1; E2F transcription factor 1; PBR3; Retinoblastoma-associated protein 1; RBAP-1; Retinoblastoma-binding protein 3; RBBP-3; pRB-binding protein E2F-1

E2F1

E2F1; E2F1; RBP3; E2F-1; RBAP1; RBBP3; RBBP3; E2F-1; RBAP-1; RBBP-3

E2F1_HUMAN

Polyclonal

Rabbit

Chimpanzee, Human

437

Amino acids 360-369 of Human E2F-1.

Immunoaffinity Purified

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

1 mg/ml

+4 degree C or -20 degree C, Avoid repeated freezing and thawing.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:20000 - 1:100000), IHC-P (10 ug/ml), WB (1:250 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.

Target Species: Human. Immunogen Description: Synthetic peptide from human E2F1.

Immunogen Type: Synthetic peptide. Immunogen: E2F1 antibody was raised against synthetic peptide from human E2F1. Antigen Modification: pSer364

E2F-1 (also known as transcription factor E2F-1, Retinoblastoma binding protein 3, RBBP-3, PRB-binding protein E2F-1, PBR3, Retinoblastoma-associated protein 1 and RBAP-1) is a transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3'. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses.

12669911

NP_005216.1

NM_005225.2

Q01094

46,920 Da

Activation Of BH3-only Proteins Pathway 105658!!Activation Of NOXA And Translocation To Mitochondria Pathway 105660!!Activation Of PUMA And Translocation To Mitochondria Pathway 105661!!Adipogenesis Pathway 198832!!Apoptosis Pathway 105648!!Assembly Of The Pre-replicative Complex Pathway 105821!!Association Of Licensing Factors With The Pre-replicative Complex Pathway 105900!!Bladder Cancer Pathway 83115!!Bladder Cancer Pathway 527!!CDC6 Association With The ORC:origin Complex Pathway 105823

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]

0.05 mg

495 USD