antibody

Rabbit Polyclonal to Human ICSBP / IRF8

MBS240342

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

Rabbit Polyclonal to Human ICSBP / IRF8

ICSBP / IRF8

Anti-ICSBP / IRF8 Antibody (C-Terminus) IHC-plus; IRF8; H-ICSBP; Interferon regulatory factor 8; ICSBP; ICSBP1; IRF-8; Human ICSBP; IRF8

interferon regulatory factor 8; Interferon regulatory factor 8; interferon regulatory factor 8; interferon consensus sequence binding protein 1; interferon regulatory factor 8; Interferon consensus sequence-binding protein; H-ICSBP; ICSBP

ICSBP

IRF8

IRF8; IRF8; ICSBP; IRF-8; ICSBP1; IMD32A; IMD32B; H-ICSBP; ICSBP1; IRF-8; H-ICSBP; ICSBP

IRF8_HUMAN

Polyclonal

Rabbit

Human, Mouse, Rat

426

peptide corresponding to 16 amino acids near the carboxy-terminus of human IRF8

Immunoaffinity Purified

PBS, 0.02% sodium azide.

1 mg/ml

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

IHC-P (5 ug/ml), WB (1 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

Target Species: Human. Immunogen Description: Synthetic peptide from human IRF8.

Immunogen Type: Synthetic peptide. Immunogen: ICSBP / IRF8 antibody was raised against synthetic peptide from human IRF8. Antigen Modification: C-Terminus

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta.

4504567

NP_002154.1

NM_002163.2

Q02556

48,356 Da

Cytokine Signaling In Immune System Pathway (366171); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Interferon Alpha/beta Signaling Pathway (187104); Interferon Gamma Signaling Pathway (187106); Pertussis Pathway (218111); Pertussis Pathway (218099); Type II Interferon Signaling (IFNG) Pathway (198918); Validated Targets Of C-MYC Transcriptional Repression Pathway (169353)

Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]

IRF8: Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a negative regulatory role in cells of the immune system. Interacts (via C-terminus) with TRIM21 (via C-terminus). Interacts with COPS2. By IFNG/IFN-gamma. Predominantly expressed in lymphoid tissues. Belongs to the IRF family. Protein type: Transcription factor; DNA-binding. Chromosomal Location of Human Ortholog: 16q24.1. Cellular Component: nucleoplasm; cytosol. Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding. Biological Process: transcription from RNA polymerase II promoter; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; cytokine and chemokine mediated signaling pathway; defense response to bacterium; immune response; myeloid cell differentiation; negative regulation of transcription from RNA polymerase II promoter; defense response to protozoan; phagocytosis. Disease: Monocyte And Dendritic Cell Deficiency, Autosomal Recessive; Immunodeficiency 32a

0.05 mg

495 USD