Rabbit Polyclonal to Human TRIM5 | MyBioSource MBS240305 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human TRIM5

catalog :

MBS240305

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240305

products type :

Antibody

products full name :

Rabbit Polyclonal to Human TRIM5

products short name :

TRIM5

products name syn :

Anti-TRIM5 Antibody IHC-plus; TRIM5; RNF88; RING finger protein 88; Tripartite motif containing 5; TRIM5alpha; Tripartite motif protein TRIM5; Tripartite motif-containing 5; Human TRIM5

other names :

Homo sapiens tripartite motif containing 5 (TRIM5), RefSeqGene on chromosome 11; Tripartite motif-containing protein 5; tripartite motif-containing protein 5; ring finger protein 88; tripartite motif protein TRIM5; tripartite motif containing 5 transcript variant iota; tripartite motif containing 5 transcript variant kappa; tripartite motif containing 5; RING finger protein 88

products gene name :

TRIM5

other gene names :

TRIM5; TRIM5; RNF88; TRIM5alpha; RNF88

uniprot entry name :

TRIM5_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Human

sequence length :

28915

specificity :

synthetic peptide corresponding to amino acids near the mid-region of human TRIM5a

purity :

Immunoaffinity Purified

form :

PBS, 0.02% sodium azide.

concentration :

1 mg/ml

storage stability :

Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.

tested application :

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

app notes :

IHC-P (5 ug/ml), WB (1 - 2 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide from human TRIM5.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: TRIM5 antibody was raised against synthetic peptide from human TRIM5.

products categories :

Family: Tripartite Motif

products description :

TRIM5 is a member of a broad family of otherwise unrelated proteins defined by the presence of a tripartite motif containing a RING domain, a B-box type 1, and a B-box type 2, followed by a coiled-coil region. TRIM5 has six alternately spliced isoforms, the longest of which is the a variant which also contains a carboxy-terminal B30.2 (SPRY) domain (1).

ncbi gi num :

336088646

ncbi acc num :

NP_149023.2

ncbi gb acc num :

NG_029122.1

ncbi mol weight :

29,677 Da

ncbi pathways :

Cytokine Signaling In Immune System Pathway (366171); Immune System Pathway (106386); Interferon Signaling Pathway (187103); Interferon Gamma Signaling Pathway (187106)

ncbi summary :

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

uniprot summary :

TRIM5: Isoform Alpha is a retrovirus restriction factor, which mediates species-specific, early block to retrovirus infection. Targets retroviral capsid soon after entry into the cell, and prevents reverse transcription of the virus RNA genome. Isoform Alpha trimers may make multiple contacts with the hexameric lattice of CA proteins which constitute the surface of retrovirion core, and somehow inactivate the virus. Restricts efficiently infection by N-MLV, but not HIV-1. May have E3 ubiquitin-protein ligase activity. Belongs to the TRIM/RBCC family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Ubiquitin ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin conjugating system; Ligase. Chromosomal Location of Human Ortholog: 11p15. Cellular Component: cytoplasm; cytosol. Molecular Function: identical protein binding; protein binding; protein homodimerization activity; zinc ion binding; ubiquitin-protein ligase activity; pattern recognition receptor activity; ligase activity. Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of MAPKKK cascade; viral reproduction; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; innate immune response; positive regulation of transcription factor activity; pattern recognition receptor signaling pathway; defense response to virus; activation of innate immune response; regulation of lipopolysaccharide-mediated signaling pathway; activation of NF-kappaB transcription factor

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage