antibody

Rabbit Polyclonal to Mouse GLI2

MBS240221

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, mouse

western blot, ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Mouse GLI2

GLI2

Anti-GLI2 Antibody (Internal) IHC-plus; GLI2; GLI-Kruppel family member GLI2; HPE9; Gli-2; Oncogene GLI2; Tax helper protein 2; THP; Zinc finger protein GLI2; Tax helper protein; THP2; GLI family zinc finger 2; Tax helper protein 1; THP1; Mouse GLI2

zinc finger protein GLI2; Zinc finger protein GLI2; zinc finger protein GLI2; oncogene GLI2; tax helper protein 1; tax helper protein 2; GLI-Kruppel family member GLI2; GLI family zinc finger protein 2; tax-responsive element-2 holding protein; glioma-associated oncogene family zinc finger 2; tax-responsive element-25-bp sequence binding protein; GLI family zinc finger 2; GLI family zinc finger protein 2; Tax helper protein

GLI2

GLI2; GLI2; CJS; HPE9; PHS2; THP1; THP2

GLI2_HUMAN

Polyclonal

Rabbit

Mouse

1586

Amino acids from an internal region of Mouse Gli-2.

Immunoaffinity Purified

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

1 mg/ml

Long term: -20 degree C; Short term: +4 degree C. Avoid repeat freeze-thaw cycles.

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

ELISA (1:15000 - 1:60000), IHC-P (5 ug/ml), WB (1:500 - 1:2000). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibo.

Target Species: Mouse. Immunogen Description: Synthetic peptide from mouse GLI2.

Immunogen Type: Synthetic peptide. Immunogen: GLI2 antibody was raised against synthetic peptide from mouse GLI2. Antigen Modification: Internal

Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. Gli-2 is also thought to play a role during embryogenesis.

86991432

NP_005261.2

NM_005270.4

P10070

86,482 Da

Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Degradation Of GLI2 By The Proteasome Pathway (1127540); GLI Proteins Bind Promoters Of Hh Responsive Genes To Promote Transcription Pathway (1127545); Hedgehog 'off' State Pathway (1127538); Hedgehog 'on' State Pathway (1127542); Hedgehog Signaling Pathway (198835); Hedgehog Signaling Pathway (1084754); Hedgehog Signaling Pathway (1108217); Hedgehog Signaling Events Mediated By Gli Proteins Pathway (137912)

This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]

0.05 mg

495 USD