Goat Polyclonal to Human ERG | MyBioSource MBS240205 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat Polyclonal to Human ERG

catalog :

MBS240205

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, rat, dog

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240205

products type :

Antibody

products full name :

Goat Polyclonal to Human ERG

products short name :

ERG

products name syn :

Anti-ERG Antibody (C-Terminus) IHC-plus; ERG; ERG-3; Ets-related; TMPRSS2/ERG fusion; Transcriptional regulator ERG; p55; Transforming protein ERG; Human ERG

other names :

transcriptional regulator ERG isoform 2; Transcriptional regulator ERG; transcriptional regulator ERG; ets-related; TMPRSS2/ERG fusion; v-ets erythroblastosis virus E26 oncogene like; v-ets erythroblastosis virus E26 oncogene homolog; v-ets avian erythroblastosis virus E26 oncogene related; transcriptional regulator ERG (transforming protein ERG); v-ets avian erythroblastosis virus E26 oncogene homolog; Transforming protein ERG

products gene name :

ERG

other gene names :

ERG; ERG; p55; erg-3

uniprot entry name :

ERG_HUMAN

clonality :

Polyclonal

host :

Goat

reactivity :

Gibbon, Gorilla, Human, Monkey. Predicted Reactivity: Mouse, Rat, Bat, Dog, Hamster, Horse, Xenopus (at least 90% immunogen sequence identity)

sequence length :

462

specificity :

Human ERG. This antibody is expected to recognise both reported isoforms (NP_891548.1; NP_004440.1)

purity :

Immunoaffinity Purified

form :

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

concentration :

0.5 mg/ml

storage stability :

Store at -20 degree C. Minimize freezing and thawing.

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA (1:16000), IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibod.

other info1 :

Target Species: Human. Immunogen Description: Synthetic peptide C-PNTRLPTSHMPSH from the C-terminus of human ERG (NP_891548.1; NP_004440.1; NP_001129626.1; NP_001129627.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ERG antibody was raised against synthetic peptide C-PNTRLPTSHMPSH from the C-terminus of human ERG (NP_891548.1; NP_004440.1; NP_001129626.1; NP_001129627.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Horse, Opossum, Platypus, Lizard, Xenopus (92%); Rabbit, Turkey, Chicken (85%). Antigen Modification: C-Terminus

ncbi gi num :

4758300

ncbi acc num :

NP_004440.1

ncbi gb acc num :

NM_004449.4

uniprot acc num :

P11308

ncbi mol weight :

36,541 Da

ncbi pathways :

Prostate Cancer Pathway (755440); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. More than two dozens of transcript variants generated from combinatorial usage of three alternative promoters and multiple alternative splicing events have been reported, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Apr 2014]

uniprot summary :

ERG: Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. Defects in ERG are a cause of Ewing sarcoma (ES). A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. A chromosomal aberration involving ERG is found in patients with Erwing sarcoma. Translocation t(21;22)(q22;q12) with EWSR1. Chromosomal aberrations involving ERG have been found in acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with FUS. Translocation t(X;21)(q25-26;q22) with ELF4. Belongs to the ETS family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Oncoprotein; DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: cytoplasm; ribonucleoprotein complex; nucleus. Molecular Function: protein binding; signal transducer activity; DNA binding; sequence-specific DNA binding. Biological Process: transcription from RNA polymerase II promoter; regulation of transcription from RNA polymerase II promoter; cell proliferation; multicellular organismal development; signal transduction; cell differentiation; protein amino acid phosphorylation

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage