antibody

Rabbit Polyclonal to Human MMP9 / Gelatinase B

MBS240189

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, dog, cow

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Rabbit Polyclonal to Human MMP9 / Gelatinase B

MMP9 / Gelatinase B

Anti-MMP9 / Gelatinase B Antibody (Internal) IHC-plus; MMP9; 92kd gelatinase; 92 kd type iv collagenase; 92 kDa gelatinase; 92 kDa type IV collagenase; Matrix metalloproteinase-9; MMP-9; Type V collagenase; CLG4B; Gelatinase B; GELB; Macrophage gelatinase; MANDP2; Human MMP9; Gelatinase B

matrix metalloproteinase-9 preproprotein; Matrix metalloproteinase-9; matrix metalloproteinase-9; type V collagenase; macrophage gelatinase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); 92 kDa gelatinase; 92 kDa type IV collagenase; Gelatinase B; GELB

MMP9

MMP9; MMP9; GELB; CLG4B; MMP-9; MANDP2; CLG4B; MMP-9; GELB

MMP9_HUMAN

Polyclonal

Rabbit

Gibbon, Bovine, Gorilla, Human. Predicted Reactivity: Monkey, Dog, Hamster, Rabbit (at least 90% immunogen sequence identity)

707

Human MMP9. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

0.4 mg/ml

Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC - Paraffin)

IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic 12 amino acid peptide from internal region of human MMP9. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Bovine (100%); Monkey, Dog, Hamster, Rabbit (92%); Mouse, Panda, Horse, Pig, Chicken (83%).

Immunogen Type: Synthetic peptide. Immunogen: MMP9 / Gelatinase B antibody was raised against synthetic 12 amino acid peptide from internal region of human MMP9. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Bovine (100%); Monkey, Dog, Hamster, Rabbit (92%); Mouse, Panda, Horse, Pig, Chicken (83%). Antigen Modification: Internal

Family: Protease. Subfamily: Metallopeptidase M10A

Matrix metalloproteinases (MMPs) are neutral proteinases that are involved in the breakdown and remodeling of the extracellular matrix (ECM) under a variety of physiological and pathological conditions. MMP9 is a Metallopeptidase M10A type protease and is particularly important in the pathogenesis of inflammatory, infectious, and neoplastic diseases in many organs.

74272287

NP_004985.2

NM_004994.2

P14780

78,458 Da

AGE/RAGE Pathway (698754); Activation Of Matrix Metalloproteinases Pathway (576264); Angiogenesis Pathway (198772); Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway (730306); Axon Guidance Pathway (105688); Bladder Cancer Pathway (83115); Bladder Cancer Pathway (527); CXCR4-mediated Signaling Events Pathway (137910); Collagen Degradation Pathway (730309); Collagen Formation Pathway (645288)

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]

MMP9: May play an essential role in local proteolysis of the extracellular matrix and in leukocyte migration. Could play a role in bone osteoclastic resorption. Cleaves KiSS1 at a Gly- -Leu bond. Cleaves type IV and type V collagen into large C-terminal three quarter fragments and shorter N-terminal one quarter fragments. Degrades fibronectin but not laminin or Pz-peptide. Exists as monomer or homodimer; disulfide-linked. Exists also as heterodimer with a 25 kDa protein. Macrophages and transformed cell lines produce only the monomeric form. Interacts with ECM1. Activated by 4-aminophenylmercuric acetate and phorbol ester. Up-regulated by ARHGEF4, SPATA13 and APC via the JNK signaling pathway in colorectal tumor cells. Produced by normal alveolar macrophages and granulocytes. Inhibited by histatin-3 1/24 (histatin-5). Inhibited by ECM1. Belongs to the peptidase M10A family. Protein type: Secreted; Protease; Motility/polarity/chemotaxis; EC 3.4.24.35; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 20q13.12. Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: collagen binding; identical protein binding; protein binding; zinc ion binding; metalloendopeptidase activity; endopeptidase activity. Biological Process: positive regulation of keratinocyte migration; axon guidance; extracellular matrix organization and biogenesis; ossification; macrophage differentiation; positive regulation of apoptosis; proteolysis; collagen catabolic process; extracellular matrix disassembly; ephrin receptor signaling pathway; skeletal development; leukocyte migration; embryo implantation. Disease: Metaphyseal Anadysplasia 2

0.05 mg

495 USD