Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43 | MyBioSource MBS240186 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43

catalog :

MBS240186

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dog, chicken, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240186

products type :

Antibody

products full name :

Rabbit Polyclonal to Human GJA1 / CX43 / Connexin 43

products short name :

GJA1 / CX43 / Connexin 43

products name syn :

Anti-GJA1 / CX43 / Connexin 43 Antibody (C-Terminus) IHC-plus; GJA1; Connexin-43; DFNB38; Connexin 43; Gap junction alpha-1 protein; GJAL; HSS; Gap junction protein alpha 1; ODDD; ODD; AVSD3; CX43; HLHS1; ODOD; SDTY3; Human GJA1; CX43; Connexin 43

other names :

gap junction alpha-1 protein; Gap junction alpha-1 protein; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein; gap junction protein, alpha 1, 43kDa; Connexin-43; Cx43; Gap junction 43 kDa heart protein

products gene name :

GJA1

other gene names :

GJA1; GJA1; HSS; CMDR; CX43; GJAL; ODDD; AVSD3; HLHS1; GJAL; Cx43

uniprot entry name :

CXA1_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Bovine, Dog, Guinea pig, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rabbit, Rat. Predicted Reactivity: Bat, Horse, Chicken, Xenopus (at least 90% immunogen sequence identity)

sequence length :

382

specificity :

Human GJA1 / Connexin 43. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

0.2 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (10 - 20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 16 amino acid peptide from C-terminus of human GJA1 / Connexin 43.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: GJA1 / CX43 / Connexin 43 antibody was raised against synthetic 16 amino acid peptide from C-terminus of human GJA1 / Connexin 43. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Dog, Hamster, Elephant, Panda, Rabbit, Pig, Opossum, Guinea pig (100%); Bat, Horse, Chicken, Lizard, Xenopus (94%); Trout, Salmon (88%); Zebrafish, Sea anemone, Nematode (81%). Antigen Modification: C-Terminus

products categories :

Family: Ion Channel. Subfamily: Connexin

products description :

Gap junction protein, alpha 1 is a member of the connexin gene family and a component of gap junctions. Gap junctions are composed of arrays of intercellular channels and provide a route for the diffusion of materials of low molecular weight from cell to cell. Connexin 43 is the major protein of gap junctions in the heart, and gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development.

ncbi gi num :

4504001

ncbi acc num :

NP_000156.1

ncbi gb acc num :

NM_000165.4

uniprot acc num :

P17302

ncbi mol weight :

43,008 Da

ncbi pathways :

Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Calcium Regulation In The Cardiac Cell Pathway (198906); Corticotropin-releasing Hormone Pathway (920957); EGFR1 Signaling Pathway (198782); Formation Of Annular Gap Junctions Pathway (105934); Gap Junction Pathway (83072); Gap Junction Pathway (483); Gap Junction Assembly Pathway (105928)

ncbi summary :

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]

uniprot summary :

GJA1: an integral membrane protein of the connexin family, alpha-type (group II) subfamily. Hexamers of connexin-43 form connexons, which aggregate together to form gap junctions, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Protein type: Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral; Channel, misc. Chromosomal Location of Human Ortholog: 6q22.31. Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; focal adhesion; contractile fiber; integral to plasma membrane; lysosome; early endosome; intermediate filament; fascia adherens; cytosol; lipid raft; Golgi membrane; multivesicular body; connexon complex; mitochondrial outer membrane; apical plasma membrane; gap junction; plasma membrane; lateral plasma membrane. Molecular Function: protein binding; signal transducer activity; ion transmembrane transporter activity; beta-tubulin binding; SH3 domain binding; gap junction channel activity; PDZ domain binding; receptor binding. Biological Process: lens development in camera-type eye; response to peptide hormone stimulus; apoptosis; heart development; neuron migration; milk ejection; positive regulation of vasodilation; signal transduction; elevation of cytosolic calcium ion concentration; muscle contraction; cell-cell signaling; positive regulation of glomerular filtration; negative regulation of cardiac muscle cell proliferation; transport; response to glucose stimulus; positive regulation of striated muscle development; heart looping; adult heart development; ATP transport; chronic inflammatory response; positive regulation of I-kappaB kinase/NF-kappaB cascade; gap junction assembly; epithelial cell maturation; in utero embryonic development; regulation of bone remodeling; positive regulation of insulin secretion; skeletal muscle regeneration; regulation of calcium ion transport; vascular transport; protein oligomerization; osteoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of endothelial cell proliferation; positive regulation of vasoconstriction; positive regulation of protein catabolic process; blood vessel morphogenesis; embryonic digit morphogenesis; regulation of bone mineralization; neurite morphogenesis; response to pH. Disease: Syndactyly, Type Iii; Craniometaphyseal Dysplasia, Autosomal Recessive; Palmoplantar Keratoderma And Congenital Alopecia 1; Atrioventricular Septal Defect 3; Oculodentodigital Dysplasia; Erythrokeratodermia Variabilis Et Progressiva; Oculodentodigital Dysplasia, Autosomal Recessive; Hypoplastic Left Heart Syndrome 1

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage