Rabbit Polyclonal to Human ITGA2 / CD49b | MyBioSource MBS240181 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human ITGA2 / CD49b

catalog :

MBS240181

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS240181

products type :

Antibody

products full name :

Rabbit Polyclonal to Human ITGA2 / CD49b

products short name :

ITGA2 / CD49b

products name syn :

Anti-ITGA2 / CD49b Antibody (Extracellular Domain) IHC-plus; ITGA2; Alpha2 integrin; BR; CD49b antigen; CD49B; Integrin alpha2; Integrin Alpha 2; Integrin alpha-2; HPA-5; VLA-2; VLAA2; VLA-2 subunit alpha; Collagen receptor; GPIa; Platelet antigen Br; Platelet glycoprotein GPIa; VLA2 receptor; alpha-2 subunit; Human ITGA2; CD49b

other names :

integrin alpha-2; Integrin alpha-2; integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit; integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor); CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b

products gene name :

ITGA2

products gene name syn :

CD49b

other gene names :

ITGA2; ITGA2; BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2; CD49B; GPIa

uniprot entry name :

ITA2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Human. Predicted Reactivity: Gorilla, Monkey, Mouse, Bovine, Horse (at least 90% immunogen sequence identity)

sequence length :

1181

specificity :

Human ITGA2 / CD49b. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

0.5 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 14 amino acid peptide from extracellular domain of human ITGA2 / CD49b. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%); Gorilla, Marmoset, Mouse, Bovine, Elephant, Horse (93%); Rat, Panda, Pig (86%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: ITGA2 / CD49b antibody was raised against synthetic 14 amino acid peptide from extracellular domain of human ITGA2 / CD49b. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey (100%); Gorilla, Marmoset, Mouse, Bovine, Elephant, Horse (93%); Rat, Panda, Pig (86%). Antigen Modification: Extracellular Domain

products categories :

Family: Integrin

products description :

ITGA2 encodes integrin alpha chain 2. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing alpha integrin 2 combines with beta integrin 1 to form a collagen-binding integrin referred to as glycoprotein Ia/IIa when expressed on platelets, and very late (activation) antigen 2 ('VLA-2') when found on T-cells. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.

ncbi gi num :

116295258

ncbi acc num :

NP_002194.2

ncbi gb acc num :

NM_002203.3

uniprot acc num :

P17301

ncbi mol weight :

129,295 Da

ncbi pathways :

Arf6 Trafficking Events Pathway 137954!!Arrhythmogenic Right Ventricular Cardiomyopathy Pathway 672454!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 117293!!Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway 116129!!Axon Guidance Pathway 105688!!CHL1 Interactions Pathway 161007!!CXCR4-mediated Signaling Events Pathway 137910!!Developmental Biology Pathway 477129!!Dilated Cardiomyopathy Pathway 121494!!Dilated Cardiomyopathy Pathway 121285

ncbi summary :

This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

size :

0.05 mg

price :

495 USD