Rabbit Polyclonal to Human PGES / PTGES | MyBioSource MBS240155 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human PGES / PTGES

catalog :

MBS240155

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, dog

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240155

products type :

Antibody

products full name :

Rabbit Polyclonal to Human PGES / PTGES

products short name :

PGES / PTGES

products name syn :

Anti-PGES / PTGES Antibody (Cytoplasmic Domain) IHC-plus; PTGES; MGST1-L1; MGST1-like 1; MPGES; MPGES-1; PGES; PIG12; PP102; TP53I12; MGST1L1; MPGES1; PP1294; MGST-IV; p53-induced gene 12 protein; Prostaglandin E synthase; Human PGES; PTGES

other names :

prostaglandin E synthase; Prostaglandin E synthase; prostaglandin E synthase; MGST1-like 1; p53-induced gene 12 protein; p53-induced apoptosis protein 12; glutathione S-transferase 1-like 1; microsomal prostaglandin E synthase 1; microsomal prostaglandin E synthase-1; tumor protein p53 inducible protein 12; microsomal glutathione S-transferase 1-like 1; prostaglandin E synthase; Microsomal glutathione S-transferase 1-like 1; MGST1-L1; Microsomal prostaglandin E synthase 1; MPGES-1; p53-induced gene 12 protein

products gene name :

PGES

products gene name syn :

PTGES

other gene names :

PTGES; PTGES; PGES; MPGES; PIG12; PP102; PP1294; MGST-IV; MGST1L1; TP53I12; mPGES-1; MGST1-L1; MGST1L1; MPGES1; PGES; PIG12; MGST1-L1; MPGES-1

uniprot entry name :

PTGES_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Gorilla, Human, Rabbit. Predicted Reactivity: Monkey, Dog (at least 90% immunogen sequence identity)

sequence length :

152

specificity :

Human PTGES. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (5 - 10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 13 amino acid peptide from 1st cytoplasmic domain of human PTGES.

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: PGES / PTGES antibody was raised against synthetic 13 amino acid peptide from 1st cytoplasmic domain of human PTGES. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Rabbit (100%); Marmoset, Dog, Elephant, Panda, Pike (92%); Bovine, Hamster, Pig, Xenopus (85%). Antigen Modification: Cytoplasmic Domain

products description :

Prostaglandin E Synthase (PGES) is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. The expression of PGES is induced by the proinflammatory cytokine IL-1B and its activity is glutathione dependent. PGES is also expressed at high levels in P53 expressing cells.

ncbi gi num :

4758910

ncbi acc num :

NP_004869.1

ncbi gb acc num :

NM_004878.4

uniprot acc num :

O14684

ncbi mol weight :

17,102 Da

ncbi pathways :

Arachidonic Acid Metabolism Pathway (82991); Arachidonic Acid Metabolism Pathway (685553); Arachidonic Acid Metabolism Pathway (366); Eicosanoid Synthesis Pathway (198888); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); Synthesis Of Prostaglandins (PG) And Thromboxanes (TX) Pathway (730333)

ncbi summary :

The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses. [provided by RefSeq, Jul 2008]

uniprot summary :

PTGES: Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). Belongs to the MAPEG family. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Lipid Metabolism - arachidonic acid; Isomerase; EC 5.3.99.3; Nuclear envelope. Chromosomal Location of Human Ortholog: 9q34.3. Cellular Component: endoplasmic reticulum membrane; membrane; perinuclear region of cytoplasm; nuclear envelope lumen; integral to membrane. Molecular Function: glutathione binding; prostaglandin-E synthase activity. Biological Process: negative regulation of cell proliferation; chronic inflammatory response; response to retinoic acid; response to cytokine stimulus; cyclooxygenase pathway; arachidonic acid metabolic process; response to lipopolysaccharide; prostaglandin biosynthetic process; response to calcium ion; signal transduction; response to organic cyclic substance; acute inflammatory response; prostaglandin metabolic process

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage