Rabbit Polyclonal to Human VRL1 / TRPV2 | MyBioSource MBS240152 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human VRL1 / TRPV2

catalog :

MBS240152

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

product information

catalog number :

MBS240152

products type :

Antibody

products full name :

Rabbit Polyclonal to Human VRL1 / TRPV2

products short name :

VRL1 / TRPV2

products name syn :

Anti-VRL1 / TRPV2 Antibody (N-Terminus) IHC-plus; TRPV2; GRC; OTRPC2; Osm-9-like TRP channel 2; VRL-1; VRL1; VRL; Human VRL1; TRPV2

other names :

transient receptor potential cation channel subfamily V member 2; Transient receptor potential cation channel subfamily V member 2; transient receptor potential cation channel subfamily V member 2; OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1; transient receptor potential cation channel, subfamily V, member 2; Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1

products gene name :

VRL1

products gene name syn :

TRPV2

other gene names :

TRPV2; TRPV2; VRL; VRL1; VRL-1; VRL; TrpV2; OTRPC2; VRL-1

uniprot entry name :

TRPV2_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gorilla, Horse, Human, Monkey, Pig. Predicted Reactivity: Gibbon, Bovine, Hamster, Rabbit (at least 90% immunogen sequence identity)

sequence length :

764

specificity :

Human TRPV2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 15 amino acid peptide from N-terminus of human TRPV2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Horse, Pig (100%); Gibbon, Bovine, Hamster, Panda, Rabbit (93%); Mouse, Dog (87%); Elephant (80%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: VRL1 / TRPV2 antibody was raised against synthetic 15 amino acid peptide from N-terminus of human TRPV2. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Horse, Pig (100%); Gibbon, Bovine, Hamster, Panda, Rabbit (93%); Mouse, Dog (87%); Elephant (80%). Antigen Modification: N-Terminus

products categories :

Family: Ion Channel. Subfamily: Calcium channel - TRP

products description :

Transient Receptor Potential Vanilloid (TRPV) channels are widely expressed in both sensory and nonsensory cells. TRPV2, a member of transient receptor potential ion channels, responds to high-threshold noxious heat (with a threshold of approximately 52 degrees C), but neither to capsaicin nor to proton. TRPV2 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat.

ncbi gi num :

20127551

ncbi acc num :

NP_057197.2

ncbi gb acc num :

NM_016113.4

uniprot acc num :

Q9Y5S1

ncbi mol weight :

85,981 Da

ncbi pathways :

Inflammatory Mediator Regulation Of TRP Channels Pathway (948277); Inflammatory Mediator Regulation Of TRP Channels Pathway (948307); Ion Channel Transport Pathway (187193); Stimuli-sensing Channels Pathway (771568); TRP Channels Pathway (906028); Transmembrane Transport Of Small Molecules Pathway (106572)

ncbi summary :

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

uniprot summary :

TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily. Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, cation. Chromosomal Location of Human Ortholog: 17p11.2. Cellular Component: cell surface; integral to plasma membrane; melanosome; plasma membrane; endomembrane system. Molecular Function: calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity. Biological Process: response to temperature stimulus; response to heat; transport; positive regulation of axon extension; sensory perception; transmembrane transport

size1 :

0.05 mg

price1 :

495 USD