Rabbit Polyclonal to Human FAP Alpha | MyBioSource MBS240132 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human FAP Alpha

catalog :

MBS240132

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240132

products type :

Antibody

products full name :

Rabbit Polyclonal to Human FAP Alpha

products short name :

FAP Alpha

products name syn :

Anti-FAP Alpha Antibody (Extracellular Domain) IHC-plus; DPPIV; FAP alpha; Fibroblast activation protein; FAPA; Seprase; Human FAP Alpha

other names :

prolyl endopeptidase FAP isoform 1; Prolyl endopeptidase FAP; prolyl endopeptidase FAP; seprase; FAPalpha; dipeptidyl peptidase FAP; surface-expressed protease; post-proline cleaving enzyme; gelatine degradation protease FAP; integral membrane serine protease; serine integral membrane protease; 170 kDa melanoma membrane-bound gelatinase; fibroblast activation protein, alpha; 170 kDa melanoma membrane-bound gelatinase; Dipeptidyl peptidase FAP; Fibroblast activation protein alpha; Gelatine degradation protease FAP; Integral membrane serine protease; Post-proline cleaving enzyme; Surface-expressed protease;

products gene name :

FAP

other gene names :

FAP; FAP; FAPA; SIMP; DPPIV

uniprot entry name :

SEPR_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Gorilla, Human. Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)

sequence length :

760

specificity :

Human FAP. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (2.5 - 5 ug/ml)

other info1 :

Target Species: Human. Immunogen Description: Synthetic 18 amino acid peptide from extracellular domain of human FAP. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Bovine (89%); Marmoset (83%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: FAP Alpha antibody was raised against synthetic 18 amino acid peptide from extracellular domain of human FAP. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Bovine (89%); Marmoset (83%). Antigen Modification: Extracellular Domain

products categories :

Family: Protease. Subfamily: Serine S9

products description :

Fibroblast Activation Protein Alpha (FAP) is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. FAP is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis.

ncbi gi num :

16933540

ncbi acc num :

NP_004451.2

ncbi gb acc num :

NM_004460.3

uniprot acc num :

Q12884

ncbi mol weight :

26,954 Da

ncbi summary :

The protein encoded by this gene is a homodimeric integral membrane gelatinase belonging to the serine protease family. It is selectively expressed in reactive stromal fibroblasts of epithelial cancers, granulation tissue of healing wounds, and malignant cells of bone and soft tissue sarcomas. This protein is thought to be involved in the control of fibroblast growth or epithelial-mesenchymal interactions during development, tissue repair, and epithelial carcinogenesis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]

uniprot summary :

FAP: In association with DPP4 is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. May have a role in tissue remodeling during development and wound healing, and may contribute to invasiveness in malignant cancers. Belongs to the peptidase S9B family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: EC 3.4.21.26; Protease; EC 3.4.14.5; Membrane protein, integral. Chromosomal Location of Human Ortholog: 2q23. Cellular Component: extracellular space; cell surface; focal adhesion; apical part of cell; lamellipodium; cytoplasm; integral to membrane; plasma membrane. Molecular Function: peptidase activity; integrin binding; protein dimerization activity; protein binding; protein homodimerization activity; protease binding; serine-type peptidase activity; dipeptidyl-peptidase activity; metalloendopeptidase activity; serine-type endopeptidase activity; endopeptidase activity. Biological Process: proteolysis involved in cellular protein catabolic process; endothelial cell migration; angiogenesis; cell adhesion; proteolysis; regulation of fibrinolysis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage