product summary
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company name :
MyBioSource
product type :
antibody
product name :
Rabbit Polyclonal to Human PDE9A
catalog :
MBS240113
quantity :
0.05 mg
price :
495 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, dog, chicken, cow
application :
immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
product information
catalog number :
MBS240113
products type :
Antibody
products full name :
Rabbit Polyclonal to Human PDE9A
products short name :
PDE9A
products name syn :
Anti-PDE9A Antibody (Internal) IHC-plus; PDE9A; Pde9A1; Pde9a2; Pde9a3; Pde9a4; Phosphodiesterase 9A; Phosphodiesterase PDE9A21; HSPDE9A2; Human PDE9A
other names :
high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A isoform a; High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; high affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; phosphodiesterase PDE9A21; CGMP-specific 3',5'-cyclic phosphodiesterase type 9; phosphodiesterase 9A
products gene name :
PDE9A
other gene names :
PDE9A; PDE9A; HSPDE9A2
uniprot entry name :
PDE9A_HUMAN
clonality :
Polyclonal
host :
Rabbit
reactivity :
Gibbon, Dog, Human, Monkey. Predicted Reactivity: Gorilla, Mouse, Bat, Bovine, Pig, Chicken (at least 90% immunogen sequence identity)
sequence length :
593
specificity :
Human PDE9A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
purity :
Immunoaffinity Purified
form :
PBS, 0.1% sodium azide.
concentration :
1 mg/ml
storage stability :
Long term: -70 degree C; Short term: +4 degree C
tested application :
Immunohistochemistry (IHC - Paraffin)
app notes :
IHC-P (20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.
other info1 :
Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from internal region of human PDE9A. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog (100%); Gorilla, Mouse, Bat, Bovine, Panda, Pig, Turkey, Chicken (94%); Rat (88%).
other info2 :
Immunogen Type: Synthetic peptide. Immunogen: PDE9A antibody was raised against synthetic 17 amino acid peptide from internal region of human PDE9A. Percent identity with other species by BLAST analysis: Human, Gibbon, Monkey, Marmoset, Dog (100%); Gorilla, Mouse, Bat, Bovine, Panda, Pig, Turkey, Chicken (94%); Rat (88%); Elephant, Platypus, Lizard (82%). Antigen Modification: Internal
products categories :
Family: Phosphodiesterase. Subfamily: PDE - cGMP-specific
products description :
Phosphodiesterase 9A is a cGMP-specific phosphodiesterase. PDE9A activity is inhibited by zaprinast, but it is insensitive to rolipram, vinpocetine, SKF-94120, dipyridamole, and IBMX. More than 20 alternatively spliced variants have been reported (Rentero et al. 2003).
ncbi gi num :
4505675
ncbi acc num :
NP_002597.1
ncbi gb acc num :
NM_002606.2
uniprot acc num :
O76083
ncbi mol weight :
56,554 Da
ncbi pathways :
Hemostasis Pathway (106028); Nitric Oxide Stimulates Guanylate Cyclase Pathway (187200); Platelet Homeostasis Pathway (187198); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307); Regulation Of Androgen Receptor Activity Pathway (138027); CGMP Effects Pathway (187201)
ncbi summary :
The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding monophosphates. The encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
uniprot summary :
PDE9A: Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE9 subfamily. 16 isoforms of the human protein are produced by alternative splicing. Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.35. Chromosomal Location of Human Ortholog: 21q22.3. Cellular Component: Golgi apparatus; endoplasmic reticulum; perinuclear region of cytoplasm; perikaryon; cytosol. Molecular Function: 3 ,5 -cyclic-GMP phosphodiesterase activity; protein binding; metal ion binding; 3 ,5 -cyclic-nucleotide phosphodiesterase activity. Biological Process: cGMP-mediated signaling; metabolic process; blood coagulation; signal transduction
size1 :
0.05 mg
price1 :
495 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
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