Rabbit Polyclonal to Human PDE7A | MyBioSource MBS240106 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human PDE7A

catalog :

MBS240106

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, rat, dog, cow

application :

immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240106

products type :

Antibody

products full name :

Rabbit Polyclonal to Human PDE7A

products short name :

PDE7A

products name syn :

Anti-PDE7A Antibody (N-Terminus) IHC-plus; PDE7A; PDE7A1; PDE7A2; Phosphodiesterase 7A; Phosphodiesterase isozyme 7; PDE7; HCP1; TM22; Human PDE7A

other names :

high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c; High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A; TM22; phosphodiesterase isozyme 7; phosphodiesterase 7A; HCP1; TM22

products gene name :

PDE7A

other gene names :

PDE7A; PDE7A; HCP1; PDE7

uniprot entry name :

PDE7A_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Bat, Gibbon, Bovine, Dog, Xenopus, Gorilla, Human, Monkey, Orangutan, Rabbit. Predicted Reactivity: Mouse, Rat, Hamster (at least 90% immunogen sequence identity)

sequence length :

482

specificity :

Human PDE7A. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

0.4 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin)

app notes :

IHC-P (20 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from N-terminus of human PDE7A. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Elephant, Panda, Rabbit, Opossum, Xenopus (100%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: PDE7A antibody was raised against synthetic 17 amino acid peptide from N-terminus of human PDE7A. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey, Marmoset, Bovine, Dog, Bat, Elephant, Panda, Rabbit, Opossum, Xenopus (100%); Mouse, Rat, Hamster, Turkey, Lizard (94%); Zebrafish (82%). Antigen Modification: N-Terminus

products categories :

Family: Phosphodiesterase. Subfamily: PDE - cAMP-specific

products description :

Phosphodiesterase 7A, a cAMP-specific phosphodiesterase, has been shown to affect memory, T-cell functioning and emesis and has been implicated in depression. Two isoforms (PDE7A1 and PDE7A2) which differ at their N-terminal region, have been reported.

ncbi gi num :

334085277

ncbi acc num :

NP_001229247.1

ncbi gb acc num :

NM_001242318.2

uniprot acc num :

Q13946

ncbi mol weight :

48,828 Da

ncbi pathways :

G Protein Signaling Pathways (198849); G Alpha (s) Signalling Events Pathway (119549); GPCR Downstream Signaling Pathway (119548); Morphine Addiction Pathway (552665); Morphine Addiction Pathway (554808); Purine Metabolism Pathway (82944); Purine Metabolism Pathway (307); Signal Transduction Pathway (477114); Signaling By GPCR Pathway (106356)

ncbi summary :

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]

uniprot summary :

PDE7A: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Nucleotide Metabolism - purine; EC 3.1.4.53; Phosphodiesterase. Chromosomal Location of Human Ortholog: 8q13. Cellular Component: cytosol. Molecular Function: 3 ,5 -cyclic-AMP phosphodiesterase activity; metal ion binding. Biological Process: cAMP catabolic process; signal transduction

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage