antibody

Rabbit Polyclonal to Human RARB / RAR Beta

MBS240096

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, chicken

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Human RARB / RAR Beta

RARB / RAR Beta

Anti-RARB / RAR Beta Antibody (C-Terminus) IHC-plus; RARB; HBV-activated protein; NR1B2; RAR Beta; RAR-beta; RAR beta4; Retinoic acid receptor beta; RAR beta1; RAR beta2; RARbeta; Retinoic acid receptor; beta; RAR beta3; RAR-epsilon; RARb2; RRB2; Human RARB; RAR Beta

retinoic acid receptor beta isoform 1; Retinoic acid receptor beta; retinoic acid receptor beta; RAR-beta; RAR-epsilon; HBV-activated protein; hepatitis B virus activated protein; retinoic acid receptor, beta polypeptide; nuclear receptor subfamily 1 group B member 2; retinoic acid receptor, beta; HBV-activated protein; Nuclear receptor subfamily 1 group B member 2; RAR-epsilon

RARB

RARB; RARB; HAP; RRB2; NR1B2; MCOPS12; HAP; NR1B2; RAR-beta

RARB_HUMAN

Polyclonal

Rabbit

Bat, Gibbon, Gorilla, Horse, Human, Monkey, Pig. Predicted Reactivity: Dog, Chicken (at least 90% immunogen sequence identity)

448

Human RARB. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml

Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

ELISA, IHC-P (10 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic 13 amino acid peptide from C-terminus of human RARB. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Horse, Pig, Opossum (100%); Dog, Turkey, Chicken (92%); Mouse, Panda (85%).

Immunogen Type: Synthetic peptide. Immunogen: RARB / RAR Beta antibody was raised against synthetic 13 amino acid peptide from C-terminus of human RARB. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat, Horse, Pig, Opossum (100%); Dog, Turkey, Chicken (92%); Mouse, Panda (85%). Antigen Modification: C-Terminus

Family: NHR. Subfamily: NR1 Thyroid hormone-like

Retinoic acid receptor beta (RAR beta), a NR1 Thyroid Hormone-Like Receptor, is involved in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. RAR beta forms heterodimers with the retinoic acid X receptor (RXR) and binds to the direct repeat 1 (DR1) sequence of target DNA. A growing body of evidence supports the hypothesis that RAR beta is a tumor-suppressor gene.

14916494

NP_000956.2

NM_000965.4

P10826

Da

Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Integrated Pancreatic Cancer Pathway (711360); Non-small Cell Lung Cancer Pathway (83119); Non-small Cell Lung Cancer Pathway (531); Nuclear Receptor Transcription Pathway (105979); Nuclear Receptors Pathway (198848); Nuclear Receptors In Lipid Metabolism And Toxicity Pathway (198887); Orphan Transporters Pathway (1127546); Pathways In Cancer (83105)

This gene encodes retinoic acid receptor beta, a member of the thyroid-steroid hormone receptor superfamily of nuclear transcriptional regulators. This receptor localizes to the cytoplasm and to subnuclear compartments. It binds retinoic acid, the biologically active form of vitamin A which mediates cellular signalling in embryonic morphogenesis, cell growth and differentiation. It is thought that this protein limits growth of many cell types by regulating gene expression. The gene was first identified in a hepatocellular carcinoma where it flanks a hepatitis B virus integration site. Alternate promoter usage and differential splicing result in multiple transcript variants. [provided by RefSeq, Mar 2014]

RARB: is a receptor for retinoic acid, a potent mammalian morphogen and teratogen that has profound effects on vertebrate development. RARB is a member of the nuclear receptor superfamily. Controls cell function by directly regulating gene expression. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain. Four splice-variant isoforms have been described. Isoform beta-1 and beta-2 are nuclear and isoform beta-4 cytoplasmic. Protein type: Oncoprotein; Motility/polarity/chemotaxis; Nuclear receptor. Chromosomal Location of Human Ortholog: 3p24.2. Cellular Component: nucleoplasm; cytoplasm; nucleus. Molecular Function: retinoid X receptor binding; protein binding; DNA binding; zinc ion binding; protein complex binding; steroid hormone receptor activity; drug binding; retinoic acid receptor activity. Biological Process: retinoic acid receptor signaling pathway; transcription initiation from RNA polymerase II promoter; regulation of myelination; glandular epithelial cell development; striatum development; positive regulation of apoptosis; embryonic eye morphogenesis; multicellular organism growth; negative regulation of chondrocyte differentiation; ventricular cardiac muscle cell differentiation; negative regulation of transcription from RNA polymerase II promoter; signal transduction; embryonic hindlimb morphogenesis; negative regulation of cell proliferation; ureteric bud development; positive regulation of cell proliferation; gene expression; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; positive regulation of neuron differentiation; transmembrane transport; embryonic gut development; negative regulation of apoptosis. Disease: Microphthalmia, Syndromic 12

0.05 mg

495 USD