antibody

Rabbit Polyclonal to Human TACR2 / Nk2 / NK2R

MBS240078

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

human, dog, cow

ELISA, immunohistochemistry, enzyme immunoassay

Antibody

Rabbit Polyclonal to Human TACR2 / Nk2 / NK2R

TACR2 / Nk2 / NK2R

Anti-TACR2 / Nk2 / NK2R Antibody (C-Terminus) IHC-plus; TACR2; Neurokinin 2 receptor; NK-2 receptor; Neurokinin A receptor; NK2; NK2R; Tachykinin receptor 2; Substance-K receptor; NK-2R; SK receptor; SKR; TAC2R; NKNAR; Substance K receptor; Human TACR2; Nk2; NK2R

substance-K receptor; Substance-K receptor; substance-K receptor; NK-2R; NK-2 receptor; substance K receptor; neurokinin 2 receptor; neurokinin A receptor; seven transmembrane helix receptor; tachykinin receptor 2; NK-2 receptor; NK-2R; Neurokinin A receptor; Tachykinin receptor 2

TACR2

Nk2; NK2R

TACR2; TACR2; SKR; NK2R; NKNAR; TAC2R; NK2R; NKNAR; TAC2R; SKR; NK-2R

NK2R_HUMAN

Polyclonal

Rabbit

Human, Pig. Predicted Reactivity: Rat, Bovine, Dog, Guinea pig, Hamster, Horse, Rabbit

398

Human Neurokinin A Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TACR1 (47%).

Immunoaffinity Purified

PBS, less than 0.1% sodium azide.

1 mg/ml

Upon arrival: Aliquot and store undiluted at -20 degreeC below for up to 1 yr. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze thaw cycles.

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

ELISA, IHC-P (40 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target: TACR2/NK2R. Target Species: Human. Immunogen Species: TACR2/NK2R antibody was raised against Human. Immunogen Description: Synthetic 19 amino acid peptide from C-terminus of human Neurokinin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Pig (100%); Rat, Bovine, Dog, Hamster, Elephant, Panda, Horse, Rabbit, Guinea pig (95%).

Immunogen Type: Synthetic peptide. Immunogen: TACR2 / Nk2 / NK2R antibody was raised against synthetic 19 amino acid peptide from C-terminus of human Neurokinin A Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Pig (100%); Rat, Bovine, Dog, Hamster, Elephant, Panda, Horse, Rabbit, Guinea pig (95%); Monkey, Marmoset, Mouse, Bat (89%). Antigen Modification: C-Terminus

Family: GPCR. Subfamily: Tachykinin

NK2R is a Tachykinin Receptor activated by the neuropeptide substance K, also referred to as neurokinin A. It mediates smooth muscle contraction in central airway and may contribute to the development of asthma. Immunohistochemistry: MBS240078 was validated for use in immunohistochemistry - on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for MBS240078 was determined to be 40 ug/ml. Summary: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.

157426873

NP_001048.2

NM_001057.2

P21452

Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637)

This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. [provided by RefSeq, Jul 2008]

TACR2: This is a receptor for the tachykinin neuropeptide substance K (neurokinin A). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: substance K neuromedin-K substance P. Belongs to the G-protein coupled receptor 1 family. Protein type: Membrane protein, multi-pass; GPCR, family 1; Receptor, GPCR; Motility/polarity/chemotaxis; Membrane protein, integral. Chromosomal Location of Human Ortholog: 10q22.1. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: substance K receptor activity; protein binding; tachykinin receptor activity. Biological Process: negative regulation of luteinizing hormone secretion; tachykinin signaling pathway; intestine smooth muscle contraction; muscle contraction; operant conditioning; excretion; response to electrical stimulus; positive regulation of vascular permeability; positive regulation of acetylcholine secretion

0.05 mg

495 USD