antibody

Rabbit Polyclonal to Human AHR

MBS240050

0.05 mg

495 USD

polyclonal

rabbit

nonconjugated

immunohistochemistry, immunohistochemistry - paraffin section

Antibody

Rabbit Polyclonal to Human AHR

AHR

Anti-AHR Antibody (N-Terminus) IHC-plus; AHR; Ah receptor; AH-receptor; Aryl hydrocarbon receptor; BHLHe76; Aromatic hydrocarbon receptor; Human AHR

aryl hydrocarbon receptor; Aryl hydrocarbon receptor; aryl hydrocarbon receptor; AH-receptor; ah receptor; aromatic hydrocarbon receptor; class E basic helix-loop-helix protein 76; aryl hydrocarbon receptor; Class E basic helix-loop-helix protein 76; bHLHe76

AHR

AHR; AHR; bHLHe76; BHLHE76; Ah receptor; AhR; bHLHe76

AHR_HUMAN

Polyclonal

Rabbit

Gorilla, Human. Predicted Reactivity: Gibbon, Monkey, Horse (at least 90% immunogen sequence identity)

848

Human Aryl Hydrocarbon Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Immunoaffinity Purified

PBS, 0.1% sodium azide.

1 mg/ml

Long term: -70 degree C; Short term: +4 degree C

Immunohistochemistry (IHC - Paraffin)

IHC-P (6 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

Target Species: Human. Immunogen Description: Synthetic 16 amino acid peptide from N-terminus of human Aryl Hydrocarbon Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Bovine (88%).

Immunogen Type: Synthetic peptide. Immunogen: AHR antibody was raised against synthetic 16 amino acid peptide from N-terminus of human Aryl Hydrocarbon Receptor. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Monkey, Horse (94%); Marmoset, Bovine (88%); Bat, Dog, Hamster, Panda, Guinea pig (81%). Antigen Modification: N-Terminus

Aryl hydrocarbon receptor is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450.

4502003

NP_001612.1

NM_001621.4

P35869

96,147 Da

Adipogenesis Pathway (198832); AhR Pathway (755436); Integrated Breast Cancer Pathway (219801)

This gene encodes a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. This receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. Its ligands included a variety of aromatic hydrocarbons. [provided by RefSeq, Jul 2008]

AHR: a nuclear receptor for aryl hydrocarbons involved in xenobiotic metabolism, cell cycle regulation, and development in response to both endogenous and environmental signals. AhR was initially identified as a receptor for dioxins, which are environmental pollutants generated by waste incineration and other industrial processes . AhR ligands include polycyclic aromatic hydrocarbons, including the carcinogen benzo(a)pyrene and other components of cigarette smoke. Naturally occurring AhR ligands include flavonoids, which are aromatic plant secondary compounds commonly found in vegetables and fruits. Cytoplasmic aryl hydrocarbon receptors are found in protein complexes with heat shock proteins. Upon ligand binding, AhR dissociates from heat shock proteins and translocate to the nucleus where it dimerizes with AhR nuclear translocator (ARNT, HIF-1b). The AhR/ARNT heterodimer binds to nuclear xenobiotic response elements to control the expression of genes associated with xenobiotic metabolism, including several cytochrome P450 genes. AhR is ubiquitously expressed and is thought to play a role in regulation of cell proliferation and differentiation, cytokine expression, and xenobiotic metabolism. Research studies link AhR activity with the control of regulatory T-cell and T-helper 17 cell differentiation, regulation of the inflammatory response, and the onset of lung cancer. Protein type: Transcription factor; DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 7p15. Cellular Component: nucleoplasm; transcription factor complex; cytoplasm; nucleus. Molecular Function: protein dimerization activity; RNA polymerase II transcription factor activity, enhancer binding; protein binding; signal transducer activity; ligand-dependent nuclear receptor activity; DNA binding; sequence-specific DNA binding; protein heterodimerization activity; Hsp90 protein binding; transcription factor activity; transcription factor binding. Biological Process: prostate gland development; transcription from RNA polymerase II promoter; blood vessel development; intracellular receptor-mediated signaling pathway; apoptosis; response to toxin; positive regulation of transcription, DNA-dependent; negative regulation of transcription from RNA polymerase II promoter; cell cycle; regulation of transcription from RNA polymerase II promoter; response to xenobiotic stimulus; regulation of transcription, DNA-dependent; regulation of gene expression; xenobiotic metabolic process; positive regulation of transcription from RNA polymerase II promoter; regulation of B cell proliferation; circadian regulation of gene expression; negative regulation of transcription, DNA-dependent; positive regulation of transcriptional preinitiation complex assembly

0.05 mg

495 USD