Rabbit Polyclonal to Human CCR10 / GPR2 | MyBioSource MBS240002 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Rabbit Polyclonal to Human CCR10 / GPR2

catalog :

MBS240002

quantity :

0.05 mg

price :

495 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

ELISA, immunohistochemistry, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS240002

products type :

Antibody

products full name :

Rabbit Polyclonal to Human CCR10 / GPR2

products short name :

CCR10 / GPR2

products name syn :

Anti-CCR10 / GPR2 Antibody (N-Terminus) IHC-plus; CCR10; C-C CKR-10; CC-CKR-10; CCR-10; C-C chemokine receptor type 10; CC chemokine receptor 10; G-protein coupled receptor 2; GPR2; G protein-coupled receptor 2; Human CCR10; GPR2

other names :

C-C chemokine receptor type 10; C-C chemokine receptor type 10; C-C chemokine receptor type 10; CCR-10; CC-CKR-10; C-C CKR-10; CC chemokine receptor 10; G protein-coupled receptor 2; G-protein coupled receptor 2; chemokine (C-C motif) receptor 10; G-protein coupled receptor 2

products gene name :

CCR10

products gene name syn :

GPR2

other gene names :

CCR10; CCR10; GPR2; GPR2; C-C CKR-10; CC-CKR-10; CCR-10

uniprot entry name :

CCR10_HUMAN

clonality :

Polyclonal

host :

Rabbit

reactivity :

Gibbon, Gorilla, Human. Predicted Reactivity: Monkey, Rabbit (at least 90% immunogen sequence identity)

sequence length :

362

specificity :

Human CCR10. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

purity :

Immunoaffinity Purified

form :

PBS, 0.1% sodium azide.

concentration :

1 mg/ml

storage stability :

Long term: -70 degree C; Short term: +4 degree C

tested application :

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

app notes :

ELISA, IHC-P (5 ug/ml). Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti.

other info1 :

Target Species: Human. Immunogen Description: Synthetic 17 amino acid peptide from N-terminus of human CCR10. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Rabbit (94%); Bat, Pig (88%); Rat (82%).

other info2 :

Immunogen Type: Synthetic peptide. Immunogen: CCR10 / GPR2 antibody was raised against synthetic 17 amino acid peptide from N-terminus of human CCR10. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey, Marmoset, Rabbit (94%); Bat, Pig (88%); Rat (82%). Antigen Modification: N-Terminus

products categories :

Family: GPCR. Subfamily: Chemokine

products description :

GPR2/CCR10, a Chemokine Receptor, encodes a protein that most closely resembles the interleukin-8 receptor. The keratinocyte-produced chemokine CCL27 activates CCR10 and is involved in T cell-mediated skin inflammation.

ncbi gi num :

156104886

ncbi acc num :

NP_057686.2

ncbi gb acc num :

NM_016602.2

uniprot acc num :

P46092

ncbi mol weight :

38,416 Da

ncbi pathways :

Chemokine Receptors Bind Chemokines Pathway (106359); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (i) Signalling Events Pathway (119550); GPCR Downstream Signaling Pathway (119548)

ncbi summary :

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

uniprot summary :

CCR10: Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line. Belongs to the G-protein coupled receptor 1 family. Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass. Chromosomal Location of Human Ortholog: 17q21.1-q21.3. Cellular Component: cell surface; integral to plasma membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; C-C chemokine receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; chemotaxis

size1 :

0.05 mg

price1 :

495 USD

more info or order :

MyBioSource product webpage