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MOUSE ANTI RAT CD3:FITC/CD45RA:RPE

MBS238087

100 Tests

475 USD

Dual Color Reagent

MOUSE ANTI RAT CD3:FITC/CD45RA:RPE

CD3/CD45RA

receptor-type tyrosine-protein phosphatase C isoform 3; Receptor-type tyrosine-protein phosphatase C; receptor-type tyrosine-protein phosphatase C; Protein tyrosine phosphatase, receptor-type, c polypeptide; T200 glycoprotein; leucocyte common antigen; leukocyte common antigen A; leukocyte common antigen B; protein tyrosine phosphatase, receptor type, C; Leukocyte common antigen; L-CA; T200; CD_antigen: CD45

CD3

Ptprc; Ptprc; Lca; RT7; CD45; L-CA; T200; L-CA

PTPRC_RAT

FITC reagent: IgM (MOUSE) . RPE reagent: IgG1 (MOUSE)

IF4/OX-33

Mouse

1190

This item is a dual colour reagent recognising rat CD3 and CD45RA cell surface antigens. Clone IF4 recognises rat CD3, a cell surface antigen expressed by mature lymphocytes. Clone OX-33 recognises rat CD45RA, a cell surface antigen expressed by B-lymphocytes.

FITC/RPE. Dual Colour combination consisting of FITC conjugated and RPE conjugated monoclonal antibodies mixed in optimal ratio - lyophilised.

Prior to reconstitution store at 4 degree C. Following reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

Flow cytometry (FC/FACS)

Flow Cytometry: Use 10ul of the suggested working dilution to label 106 cell in 100ul. Flow Cytometry: Maximum Dilution: Neat

Reconstitution: Reconstitute with 1 ml distilled water. Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. 5% Sucrose

Buffer Solution: Phosphate buffered saline. Target Species: Rat

MBS238087 is a dual colour reagent recognising rat CD3 and CD45RA cell surface antigens. Clone IF4 recognises rat CD3, a cell surface antigen expressed by mature lymphocytes. Clone OX-33 recognises rat CD45RA, a cell surface antigen expressed by B-lymphocytes.

158138490

NP_001103357.1

NM_001109887.1

134,182 Da

B Cell Receptor Signaling Pathway (198486); Cell Adhesion Molecules (CAMs) Pathway (83461); Cell Adhesion Molecules (CAMs) Pathway (480); EPO Receptor Signaling Pathway (198514); Fc Gamma R-mediated Phagocytosis Pathway (114013); Fc Gamma R-mediated Phagocytosis Pathway (106590); Primary Immunodeficiency Pathway (83513); Primary Immunodeficiency Pathway (537); T Cell Receptor Signaling Pathway (198537); T Cell Receptor Signaling Pathway (83472)

member of a family of heavily glycosylated leukocyte cell surface glycoproteins; displays extensive O-glycosylation [RGD, Feb 2006]

CD45: a receptor type protein tyrosine phosphatase protein. Contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains. The first PTPAse domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Specifically expressed in hematopoietic cells. An essential regulator of T- and B-cell antigen receptor signaling. Functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. Suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Four alternatively spliced isoforms have been described. Protein type: EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine; Motility/polarity/chemotaxis. Cellular Component: internal side of plasma membrane; cell surface; focal adhesion; membrane; integral to plasma membrane; integral to membrane; plasma membrane; intracellular; cytosol; external side of plasma membrane; lipid raft. Molecular Function: heparin binding; heparan sulfate proteoglycan binding; protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase regulator activity; protein kinase binding. Biological Process: B cell proliferation; positive regulation of isotype switching to IgG isotypes; activation of MAPK activity; regulation of humoral immune response mediated by circulating immunoglobulin; regulation of cell cycle; positive regulation of T cell mediated cytotoxicity; protein amino acid dephosphorylation; T cell receptor signaling pathway; T cell proliferation; leukocyte adhesion; B cell receptor signaling pathway; positive regulation of MAPKKK cascade; negative regulation of T cell mediated cytotoxicity; positive regulation of B cell proliferation; positive regulation of T cell mediated immunity; response to gamma radiation; positive regulation of T cell proliferation; negative regulation of protein amino acid autophosphorylation; negative regulation of cytokine and chemokine mediated signaling pathway; positive regulation of gamma-delta T cell differentiation; defense response to virus; T cell differentiation; positive thymic T cell selection; regulation of B cell receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; positive regulation of humoral immune response mediated by circulating immunoglobulin; substrate-bound cell migration, cell release from substrate; negative thymic T cell selection; positive regulation of antigen receptor-mediated signaling pathway; bone marrow development; heterotypic cell-cell adhesion; stem cell development; positive regulation of T cell differentiation; dephosphorylation; B cell differentiation; release of sequestered calcium ion into cytosol; regulation of B cell differentiation; negative regulation of protein kinase activity; positive regulation of alpha-beta T cell proliferation; hemopoietic progenitor cell differentiation; immunoglobulin biosynthetic process

100 Tests

475 USD