other

MOUSE ANTI HUMAN CD79a:FITC/CD5:RPE

MBS238077

50 Tests

750 USD

Dual Color Reagent

MOUSE ANTI HUMAN CD79a:FITC/CD5:RPE

CD79a/CD5

T-cell surface glycoprotein CD5; T-cell surface glycoprotein CD5; T-cell surface glycoprotein CD5; CD5 antigen (p56-62); lymphocyte antigen T1/Leu-1; CD5 molecule; Lymphocyte antigen T1/Leu-1; CD_antigen: CD5

CD79a

CD5; CD5; T1; LEU1; LEU1

CD5_HUMAN

FITC reagent: IgG1 (MOUSE) . RPE reagent: IgG2a (MOUSE)

ZL7-4/MF7-14.5

Mouse

495

FITC/RPE. Dual Colour combination consisting of FITC conjugated and RPE conjugated monoclonal antibodies mixed in optimal ratio - lyophilised.

Prior to reconstitution store at 4 degree C. Following reconstitution store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution.

Flow cytometry (FC/FACS)

Flow Cytometry: Use 10ul to label 100ul of whole blood. Flow Cytometry: Maximum Dilution: Neat

Reconstitution: Reconstitute with 0.5 ml distilled water. Perservative Stabilisers: 0.09% Sodium Azide. 1% Bovine Serum Albumin. 5% Sucrose

Buffer Solution: Phosphate buffered saline. Target Species: Human

CD79a is part of the B cell receptor complex, and is expressed by all B lymphocytes. CD5 is a 67kD glycoprotein expressed by all mature T cells and by a subset of mature B cells. CD5 has been shown to act as a ligand for the B cell marker CD72. CD5 positive B cells have been implicated in the pathogenesis of various autoimmune disorders and are the normal counterpart of the malignant cells in B cell chronic lymphocytic leukaemia. This combination of antibodies is useful for simultaneously enumerating CD5 and CD79a positive cells. It may find particular application in the study of CD5 positive B lymphocytes and in the study of chronic lymphoproliferative diseases. The CD79a specific antibody in this combination has been reported to be useful in distinguishing B-CLL from mantle cell lymphoma, see Bell, P.B. et al. for details.

166197668

NP_055022.2

NM_014207.3

54,578 Da

B Cell Receptor Signaling Pathway (198909); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489)

CD5: a surface glycoprotein expressed on T cells and B-1 B cells. Rapidly recruited to the immunological synapse, lowering the response of the T cell antigen receptor. CD5 interacts with CD72/LYB-2. Promotes B-cell survival through stimulation of autocrine IL-10 production. Contains 3 SRCR domains. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 11q13. Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane. Molecular Function: protein binding; transmembrane receptor activity; receptor activity; scavenger receptor activity. Biological Process: cell proliferation; receptor-mediated endocytosis; T cell costimulation; cell recognition

50 Tests

750 USD