catalog number :
MBS238076
products type :
Dual Color Reagent
products full name :
MOUSE ANTI HUMAN CD10:FITC/CD19:RPE
products short name :
CD10/CD19
other names :
neprilysin; Neprilysin; neprilysin; atriopeptidase; common acute lymphocytic leukemia antigen; enkephalinase; membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase); membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10); membrane metallo-endopeptidase variant 1; membrane metallo-endopeptidase variant 2; neprilysin-390; neprilysin-411; neutral endopeptidase 24.11; skin fibroblast elastase; membrane metallo-endopeptidase; Atriopeptidase; Common acute lymphocytic leukemia antigen; CALLA; Enkephalinase; Neutral endopeptidase 24.11; NEP; Neutral endopeptidase; Skin fibroblast elastase; SFE; CD_antigen: CD10
products gene name :
CD10
other gene names :
MME; MME; NEP; SFE; CD10; CALLA; EPN; CALLA; NEP; Neutral endopeptidase; SFE
uniprot entry name :
NEP_HUMAN
isotype :
FITC reagent: IgG1 (MOUSE)
. RPE reagent: IgG1 (MOUSE)
specificity :
RXB-14 recognises the human CD10 antigen, expressed by granulocytes, pre-B cells and by cALL cells. IG9 recognises the human CD19 antigen, a pan B cell marker. This item may be used to simultaneously enumerate CD10 and CD19 positive cells.
form :
FITC/RPE. Dual Colour combination consisting of FITC conjugated and RPE conjugated monoclonal antibodies mixed in optimal ratio - liquid
storage stability :
Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. This product is photosensitive and should be protected from light. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 6 months from date of despatch.
tested application :
Flow cytometry (FC/FACS)
app notes :
Flow Cytometry: Use 10ul to label 106 cells or 100ul whole blood. Flow Cytometry: Maximum Dilution: Neat
other info1 :
Perservative Stabilisers: 0.08% Sodium Azide. 0.2% Gelatin
other info2 :
Buffer Solution: Phosphate buffered saline. Target Species: Human
products description :
RXB-14 recognises the human CD10 antigen, expressed by granulocytes, pre-B cells and by cALL cells. IG9 recognises the human CD19 antigen, a pan B cell marker. MBS238076 may be used to simultaneously enumerate CD10 and CD19 positive cells.
ncbi acc num :
NP_000893.2
ncbi gb acc num :
NM_000902.3
ncbi mol weight :
85,514 Da
ncbi pathways :
Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Hematopoietic Cell Lineage Pathway 83078!!Hematopoietic Cell Lineage Pathway 489!!Metabolism Of Angiotensinogen To Angiotensins Pathway 685555!!Metabolism Of Proteins Pathway 106230!!Peptide Hormone Metabolism Pathway 771603!!Protein Digestion And Absorption Pathway 172847!!Protein Digestion And Absorption Pathway 171868
ncbi summary :
This gene encodes a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). This protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. It is a glycoprotein that is particularly abundant in kidney, where it is present on the brush border of proximal tubules and on glomerular epithelium. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. This gene, which encodes a 100-kD type II transmembrane glycoprotein, exists in a single copy of greater than 45 kb. The 5' untranslated region of this gene is alternatively spliced, resulting in four separate mRNA transcripts. The coding region is not affected by alternative splicing. [provided by RefSeq, Jul 2008]