protein

NATIVE MOUSE NERVE GROWTH FACTOR 2.5S

MBS238050

0.01 mg

390 USD

Antigen

NATIVE MOUSE NERVE GROWTH FACTOR 2.5S

NERVE GROWTH FACTOR 2.5S

beta-nerve growth factor isoform B; Beta-nerve growth factor; beta-nerve growth factor; beta-NGF; nerve growth factor, beta; nerve growth factor

Ngf; Ngf; Ngfb; Ngfb; Beta-NGF

NGF_MOUSE

241

SDS PAGE: >95%

Purified. Purified NGF from mouse submaxillaries - lyophilised

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Shelf Life: 12 months from date of despatch.

ELISA (EIA)

Reconstitution: Dissolve product in a small volume of sterile distilled water. Stability may be enhanced by the addition of albumin. Preparation: Prepared by a modification of the method by Bocchini and Angeletti (1). Bioassayed in a rat pheochromocytoma cell line (2).

Buffer Solution: TRIS buffered saline. Target Species: Mouse

Nerve growth factor (NGF) is a protein secreted by the target of a neuron that stimulates the growth and differentiation of the sympathetic and certain sensory nerves. It consists of 3 subunits, alpha, beta and gamma, with the beta subunit having sole responsible for nerve and growth stimulating activity.

162951831

NP_001106168.1

NM_001112698.2

P01139

27,077 Da

ARMS-mediated Activation Pathway (1110440); Activation Of TRKA Receptors Pathway (1110431); Apoptosis Pathway (83257); Apoptosis Pathway (470); Apoptosis Signaling Pathway (522973); Axonal Growth Stimulation Pathway (1110427); Cell Death Signalling Via NRAGE, NRIF And NADE Pathway (1110417); Ceramide Signalling Pathway (1110425); Frs2-mediated Activation Pathway (1110439); Id Signaling Pathway (198411)

NGF: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival. Homodimer. Belongs to the NGF-beta family. Protein type: Secreted, signal peptide; Secreted. Cellular Component: extracellular space; cytoplasmic membrane-bound vesicle; extracellular region. Molecular Function: metalloendopeptidase inhibitor activity; nerve growth factor receptor binding; growth factor activity; receptor signaling protein activity; receptor binding. Biological Process: positive regulation of neuron maturation; regulation of neuron differentiation; adult locomotory behavior; positive regulation of axon extension; regulation of neurotransmitter secretion; sensory perception of pain; positive regulation of cell growth; positive regulation of protein amino acid autophosphorylation; regulation of release of sequestered calcium ion into cytosol; memory; positive regulation of nerve growth factor receptor signaling pathway; peripheral nervous system development; neuron apoptosis; induction of apoptosis via death domain receptors; positive regulation of cell proliferation; positive regulation of transcription factor activity; negative regulation of neuron apoptosis; positive regulation of neuron differentiation; positive regulation of collateral sprouting; neurite development; transmembrane receptor protein tyrosine kinase signaling pathway; neurite morphogenesis

0.01 mg

390 USD