protein

NATIVE HUMAN C1q

MBS238027

1 mg

635 USD

Antigen

NATIVE HUMAN C1q

C1q

complement C1q subcomponent subunit A; Complement C1q subcomponent subunit A; complement C1q subcomponent subunit A; complement component 1, q subcomponent, alpha polypeptide; complement component C1q, A chain; complement component 1, q subcomponent, A chain

C1q

C1QA; C1QA

C1QA_HUMAN

245

SDS PAGE: >96%. Single band at 410kDa in PAGE.

Purified. Purified C1q from human serum - lyophilised

Total protein concentration 1.0 mg/ml after reconstitution

Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 3 months from date of reconstitution.

ELISA (EIA)

Synonyms: C1QG. Reconstitution: Reconstitute with 1.0ml distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. The solution may appear cloudy following reconstitution . Preservative Stabilizer: None Present

Buffer Solution: 0.01M Na2EDTA. 0.3M NaCl, pH 7.5. Target Species: Human. Health And Safety: Donor serum tested negative for HIV1/2 antibodies. HBsAg and HCV antibodies. As no test can completely guarantee this material to be free of pathogens it should be handled as potentially infectious.

Native Human Complement Component C1q is a sub-component of complement C1. C1q associates with complement components C1r and C1s, which are required for the progression of the proteolytic complement cascade. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis.

7705753

NP_057075.1

NM_015991.2

Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Classical Antibody-mediated Complement Activation Pathway (106409); Complement Activation, Classical Pathway (198823); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); Immune System Pathway (106386)

This gene encodes a major constituent of the human complement subcomponent C1q. C1q associates with C1r and C1s in order to yield the first component of the serum complement system. Deficiency of C1q has been associated with lupus erythematosus and glomerulonephritis. C1q is composed of 18 polypeptide chains: six A-chains, six B-chains, and six C-chains. Each chain contains a collagen-like region located near the N terminus and a C-terminal globular region. The A-, B-, and C-chains are arranged in the order A-C-B on chromosome 1. This gene encodes the A-chain polypeptide of human complement subcomponent C1q. [provided by RefSeq, Jul 2008]

C1QA iso2: C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2 )-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 1p36.12. Cellular Component: collagen; extracellular region; complement component C1 complex. Molecular Function: protein binding. Biological Process: cell-cell signaling; innate immune response; complement activation, classical pathway; complement activation. Disease: C1q Deficiency

1 mg

635 USD