product summary
request information :
company name :
MyBioSource
product type :
protein
product name :
RECOMBINANT HUMAN PAI-1
catalog :
MBS232424
quantity :
0.01 mg
price :
430 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS232424
products type :
Recombinant Protein
products full name :
RECOMBINANT HUMAN PAI-1
products short name :
PAI-1
other names :
plasminogen activator inhibitor 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1
products gene name :
PAI-1
other gene names :
SERPINE1; SERPINE1; PAI; PAI1; PAI-1; PLANH1; PAI1; PLANH1; PAI; PAI-1
uniprot entry name :
PAI1_HUMAN
sequence length :
402
purity :
>95% by SDS PAGE and HPLC analysis
form :
Purified recombinant protein - lyophilised
concentration :
Approximate Protein Concentration: 0.1mg/ml after reconstitution
storage stability :
Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 3 months from date of reconstitution.
tested application :
Functional Assays (FN)
other info1 :
Reconstitution: Reconstitute with 100ul distilled water. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. For extended sotrage, the addition of 0.1% BSA is recommended. Preparation: Purified recombinant PAI-1 expressed in E Coli.
other info2 :
Buffer Solution: 10mM Sodium Phosphate. Activity: Determined by its inhibitory effect against single chain tPA induced cleavage of a chromogenic substrate in Imidazole Buffer at 37 degree C. Half maximal inhibition against 1.0 mug/ml of single chain tPA was obtained at a concentration of 2.0 mug/ml. Target Species: Human
products description :
PAI-1 (plasminogen activator inhibitor-1) is a serine protease inhibitor and member of the serpin family, which acts as the primary inhibitor of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), and hence fibrinolysis. Increased levels of PAI-1 are associated with diabetes, cardiovascular disease and an increased occurrence of thrombosis in obesity, and can be induced by obesity related factors including insulin, glucose and VLDL (very-low-density lipoprotein).
ncbi gi num :
10835159
ncbi acc num :
NP_000593.1
ncbi gb acc num :
NM_000602.4
uniprot acc num :
P05121
ncbi mol weight :
42.7kD (379 amino acid residues).
ncbi pathways :
Adipogenesis Pathway 198832!!BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway 477138!!Blood Clotting Cascade Pathway 198840!!Chagas Disease (American Trypanosomiasis) Pathway 147809!!Chagas Disease (American Trypanosomiasis) Pathway 147795!!Circadian Clock Pathway 187173!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Direct P53 Effectors Pathway 137939
ncbi summary :
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
size :
0.01 mg
price :
430 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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