protein

RECOMBINANT HUMAN FGF ACIDIC

MBS232235

0.05 mg

430 USD

Recombinant Protein

RECOMBINANT HUMAN FGF ACIDIC

FGF ACIDIC

fibroblast growth factor 1 isoform 1; Fibroblast growth factor 1; fibroblast growth factor 1; beta-endothelial cell growth factor; endothelial cell growth factor, alpha; endothelial cell growth factor, beta; heparin-binding growth factor 1; fibroblast growth factor 1 (acidic); Acidic fibroblast growth factor; aFGF; Endothelial cell growth factor; ECGF; Heparin-binding growth factor 1; HBGF-1

FGF

FGF1; FGF1; AFGF; ECGF; FGFA; ECGFA; ECGFB; FGF-1; HBGF1; HBGF-1; GLIO703; ECGF-beta; FGF-alpha; FGFA; FGF-1; aFGF; ECGF; HBGF-1

FGF1_HUMAN

155

>95% by SDS PAGE and HPLC analysis

Rec. Protein. Purified - lyophilised

Approximate Protein Concentration: 1 mg/ml after reconstitution

Prior to reconstitution store at 4 degree C. Following reconstitution store at -20 degree C. This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 3 months from date of reconstitution.

Functional Assays (FN)

Reconstitution: Reconstitute with 50ul of 5mM Sodium Phosphate, pH 8.0. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommend that the vial is gently vortexed after reconstitution and microcentrifuged before use. Preparation: Recombinant protein expressed in E Coli.

Activity: 1 x 105 units/mg. Target Species: Human

Human FGF acidic, also known as FGF 1 (fibroblast growth factor 1), is a member of the heparin-binding growth factor family, widely distributed in the peripheral and central nervous systems. FGF 1 acts as a potent neurotrophic factor, playing a key role during prenatal development and postnatal growth/regeneration and is dependent upon interactions with heparin sulfate (HS) proteoglycans located on cell surfaces and in the extracellular matrix, and the four high affinity tyrosine kinase receptors, designated FGFR-1,-2,-3 and -4. Bioactivity was determined by the dose-dependent stimulation of thymidine uptake by FGF receptor-expressing BaF3 cells. The ED50 is

4503697

NP_000791.1

NM_000800.4

P05230

Protein Molecular Weight: 15.8 kDa (140 Amino Acid Sequence)

Activated Point Mutants Of FGFR2 Pathway 645281!!Adaptive Immune System Pathway 366160!!Constitutive PI3K/AKT Signaling In Cancer Pathway 685535!!DAP12 Interactions Pathway 685549!!DAP12 Signaling Pathway 685550!!Disease Pathway 530764!!Downstream Signal Transduction Pathway 106385!!Downstream Signaling Events Of B Cell Receptor (BCR) Pathway 576250!!Downstream Signaling Of Activated FGFR Pathway 160957!!FGF Signaling Pathway 137989

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Jan 2009]

0.05 mg

430 USD