protein

NATIVE HUMAN C-REACTIVE PROTEIN

MBS230380

1 mg

275 USD

Native Protein

NATIVE HUMAN C-REACTIVE PROTEIN

[C-REACTIVE PROTEIN]

[C-reactive protein; C-reactive protein; C-reactive protein; pentraxin 1; C-reactive protein, pentraxin-related]

[CRP; CRP; PTX1; PTX1]

CRP_HUMAN

224

>99%

Purified. Purified protein - liquid

Approximate Protein Concentration: 1.0 mg/ml

Store at 4°C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

ELISA (EIA)

Preservative Stabilisers: 0.09% Sodium Azide (NaN 3 ) . Preparation: 0.2 uM sterile filtered.

Buffer Solution: Tris buffered saline, 5 mM CaCl 2 . Target Species: Human

C-reactive protein is an acute phase protein, produced by the liver that is used as a marker of inflammation and for monitoring and predicting coronary artery disease. It exists in the blood as a large pentamer of approximately 114 kDa.

55770842

NP_000558.2

NM_000567.2

P02741

114 kDa

Classical Antibody-mediated Complement Activation Pathway (106409); Complement Cascade Pathway (106405); Creation Of C4 And C2 Activators Pathway (106407); IL6-mediated Signaling Events Pathway (137932); Immune System Pathway (106386); Initial Triggering Of Complement Pathway (106406); Innate Immune System Pathway (106387); Selenium Pathway (198825)

The protein encoded by this gene belongs to the pentaxin family. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. [provided by RefSeq, Sep 2009]

CRP: Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. Belongs to the pentaxin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1q23.2. Cellular Component: extracellular space; growth cone; extracellular region; filopodium. Molecular Function: choline binding; protein binding; protein homodimerization activity; low-density lipoprotein receptor binding; complement component C1q binding; low-density lipoprotein binding; virion binding; cholesterol binding; calcium ion binding. Biological Process: protein polymerization; wound healing; defense response to Gram-positive bacterium; response to ethanol; negative regulation of vasodilation; positive regulation of superoxide release; response to lead ion; response to hypoxia; acute-phase response; opsonization; inflammatory response; complement activation, classical pathway; aging

1 mg

275 USD