protein

PURIFIED HUMAN ALPHA FETOPROTEIN

MBS230298

1 mg

1185 USD

Purified Protein

PURIFIED HUMAN ALPHA FETOPROTEIN

ALPHA FETOPROTEIN

alpha-fetoprotein; Alpha-fetoprotein; alpha-fetoprotein; alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin

AFP; AFP; AFPD; FETA; HPAFP; HPAFP

FETA_HUMAN

609

>95%.

Purified. Purified human alpha fetoprotein - liquid

Total protein concentration 1.0 mg/ml

Store at 4 degree C. DO NOT FREEZE. This product should be stored undiluted. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

Immunoassay (IY)

Perservative Stabilisers: 0.1% Sodium Azide (NaN3) . Preparation: Purified human alpha fetoprotein from human cord serum.

Buffer Solution: TRIS buffered saline. Target Species: Human

This product is a 63 kDa protein which binds copper, nickel, fatty acids, bilirubin and serum albumin. It is expressed mostly during foetal development, existing only at very low levels in healthy adults. Alpha fetoprotein is therefore a useful marker for diseases such as hepatocellular carcinoma, testicular cancer, Downs syndrome and neural tube defects.

4501989

NP_001125.1

NM_001134.2

P02771

63kD

Direct P53 Effectors Pathway (137939); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Glucocorticoid Receptor Regulatory Network Pathway (138014); Hippo Signaling Pathway (749777); Hippo Signaling Pathway (750388)

This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Jul 2008]

AFP: Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. Dimeric and trimeric forms have been found in addition to the monomeric form. Plasma. Synthesized by the fetal liver and yolk sac. Belongs to the ALB/AFP/VDB family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 4q13.3. Cellular Component: extracellular space; cytoplasm. Molecular Function: metal ion binding. Biological Process: transport; progesterone metabolic process; ovulation from ovarian follicle. Disease: Alpha-fetoprotein Deficiency; Alpha-fetoprotein, Hereditary Persistence Of

1 mg

1185 USD