catalog number :
MBS230288
products type :
Purified Protein
products full name :
PURIFIED HUMAN SECRETORY IgA
products short name :
IgA
other names :
Ig alpha-1 chain C region, partial; Ig alpha-1 chain C region; immunoglobulin heavy constant alpha 1
other gene names :
IGHA1; IGHA1; IgA1
uniprot entry name :
IGHA1_HUMAN
form :
Purified. Purified IgA - liquid
concentration :
Approximate Protein Concentration: 1.0 mg/ml
storage stability :
Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.
tested application :
ELISA (EIA)
other info1 :
Preparation: Purified human secretory IgA prepared by size-exclusion and ion exchange chromatography.
other info2 :
Buffer Solution: Phosphate buffered saline . Target Species: Human. Preservative Stabilisers: None Present
products description :
Purified Human Secretory IgA is derived from human colostrum and is predominately in dimeric form, the monomers being linked by immunoglobulin J chain.
ncbi mol weight :
37,655 Da
ncbi pathways :
Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Inflammatory Response Pathway (198766); Regulation Of Nuclear SMAD2/3 Signaling Pathway (137963); Scavenging Of Heme From Plasma Pathway (771600)
uniprot summary :
IGHA1: Ig alpha is the major immunoglobulin class in body secretions. It may serve both to defend against local infection and to prevent access of foreign antigens to the general immunologic system. A chromosomal aberration involving IGHA1 is found in multiple myeloma (MM) cell lines. Translocation t(1;14)(q21;q32) that forms a FCRL4-IGHA1 fusion protein. Protein type: Immunoglobulin superfamily. Chromosomal Location of Human Ortholog: 14q32.33. Cellular Component: extracellular space; extracellular region. Molecular Function: antigen binding. Biological Process: retinal homeostasis; receptor-mediated endocytosis; glomerular filtration; antibacterial humoral response; immune response; protein-chromophore linkage