protein

NATIVE HUMAN TENASCIN

MBS230239

0.1 mg

860 USD

Purified Protein

NATIVE HUMAN TENASCIN

TENASCIN

tenascin; Tenascin; tenascin; GP 150-225; cytotactin; deafness, autosomal dominant 56; glioma-associated-extracellular matrix antigen; hexabrachion (tenascin); myotendinous antigen; neuronectin; tenascin-C additional domain 1; tenascin-C isoform 14/AD1/16; tenascin C; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C

TNC; TNC; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; HXB; TN; TN-C

TENA_HUMAN

2201

>97% by SDS PAGE

Purified. Purified protein from tissue culture supernatant - liquid

Total protein concentration 0.1mg/ml

Store at -70 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

ELISA (EIA)

Preparation: This item was purified from tissue culture supernatant of the overproducing cell line, U251, using precipitation, concentration and dialysis.

Buffer Solution: Phosphate buffered saline. Target Species: Human

MBS230239 is purified human Tenascin, a secreted peptide found in the extracellular matrix that plays an active role in the development of the CNS and mesenchymal derived organs. It is also present in adult tumour vasculature and has functions in cell adhesion.

153946395

NP_002151.2

NM_002160.3

P24821

171,360 Da

ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Integrin Cell Surface Interactions Pathway (106110); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)

This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]

TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q33. Cellular Component: extracellular matrix; extracellular space; focal adhesion; membrane; extracellular region; basement membrane. Molecular Function: syndecan binding. Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; response to ethanol; wound healing; response to mechanical stimulus; positive regulation of cell proliferation; response to wounding; negative regulation of cell adhesion; cell adhesion; axon regeneration in the peripheral nervous system; neuromuscular junction development; odontogenesis of dentine-containing teeth. Disease: Deafness, Autosomal Dominant 56

0.1 mg

860 USD