NATIVE HUMAN RETINOL BINDING PROTEIN | MyBioSource MBS230233 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

NATIVE HUMAN RETINOL BINDING PROTEIN

catalog :

MBS230233

quantity :

1 mg

price :

565 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS230233

products type :

Purified Protein

products full name :

NATIVE HUMAN RETINOL BINDING PROTEIN

products short name :

RETINOL BINDING PROTEIN

other names :

retinol-binding protein 4; Retinol-binding protein 4; retinol-binding protein 4; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial; retinol binding protein 4, plasma; Plasma retinol-binding protein; PRBP; RBP

other gene names :

RBP4; RBP4; RDCCAS; PRBP; RBP

uniprot entry name :

RET4_HUMAN

sequence length :

201

purity :

SDS PAGE: >96%

form :

Purified. Purified protein from the urine of patients with chronic renal tubular proteinuria - lyophilized

concentration :

Approximate Protein Concentration: 1.0 mg/ml after reconstitution

storage stability :

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Shelf Life: 12 months from date of despatch.

tested application :

ELISA (EIA)

other info1 :

Reconstitution: Reconstitute with 1.0 ml sterile phosphate buffered saline. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.

other info2 :

Buffer Solution: Ammonium bicarbonate. Target Species: Human

products description :

MBS230233 is purified human retinol binding protein, a secreted peptide that delivers retinol from liver stores to the peripheral tissues.

ncbi gi num :

55743122

ncbi acc num :

NP_006735.2

ncbi gb acc num :

NM_006744.3

uniprot acc num :

P02753

ncbi mol weight :

21 kDa

ncbi pathways :

Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Retinoid Cycle Disease Events Pathway (771582); Retinoid Metabolism And Transport Pathway (187208); SREBP Signalling Pathway (219802); Signal Transduction Pathway (477114); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (771585); Visual Phototransduction Pathway (771584); Vitamin A And Carotenoid Metabolism Pathway (198785); Retinoate Biosynthesis I Pathway (545452)

ncbi summary :

This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]

uniprot summary :

RBP4: Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 are a cause of retinol-binding protein deficiency (RBP deficiency). This condition causes night vision problems. It produces a typical fundus xerophthalmicus , featuring a progressed atrophy of the retinal pigment epithelium. Belongs to the calycin superfamily. Lipocalin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 10q23.33. Cellular Component: extracellular space; protein complex; extracellular region; cytosol. Molecular Function: protein binding; protein heterodimerization activity; retinal binding; retinol binding. Biological Process: phototransduction, visible light; retinal metabolic process; embryonic skeletal development; heart development; maintenance of gastrointestinal epithelium; uterus development; glucose homeostasis; response to insulin stimulus; embryonic organ morphogenesis; retinol metabolic process; negative regulation of cardiac muscle cell proliferation; detection of light stimulus involved in visual perception; retinoid metabolic process; female genitalia morphogenesis; cardiac muscle development; response to retinoic acid; urinary bladder development; male gonad development; positive regulation of insulin secretion; vagina development; positive regulation of immunoglobulin secretion; gluconeogenesis; response to ethanol; eye development; embryonic retina morphogenesis in camera-type eye; spermatogenesis; lung development. Disease: Retinal Dystrophy, Iris Coloboma, And Comedogenic Acne Syndrome; Microphthalmia, Isolated, With Coloboma 10

size1 :

1 mg

price1 :

565 USD

more info or order :

MyBioSource product webpage