protein

NATIVE HUMAN PROSTATE SPECIFIC ANTIGEN

MBS230225

0.1 mg

440 USD

Purified Protein

NATIVE HUMAN PROSTATE SPECIFIC ANTIGEN

PROSTATE SPECIFIC ANTIGEN

prostate-specific antigen isoform 3 preproprotein; Prostate-specific antigen; prostate-specific antigen; P-30 antigen; gamma-seminoprotein; kallikrein-3; prostate specific antigen; semenogelase; seminin; kallikrein-related peptidase 3; Gamma-seminoprotein; Seminin; Kallikrein-3; P-30 antigen; Semenogelase

KLK3; KLK3; APS; PSA; hK3; KLK2A1; APS; PSA; Seminin

KLK3_HUMAN

238

>96% by SDS-PAGE

Purified. Purified protein from human seminal fluid - liquid

Approximate Protein Concentration: 1.0 mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of despatch.

ELISA (EIA), Western Blot (WB)

Western Blot: This protein may be used in Western blotting applications using suitable anti prostate specific antigen antibodies for detection and analysis.

Perservative Stabilisers: 0.09% Sodium Azide (NaN3) . Preparation: Sterlie filtered through a 0.2 uM membrane

Buffer Solution: Phosphate buffered saline. Target Species: Human

MBS230225, prostate-specific antigen (PSA) is a glycoprotein of approximately 30 kDa found mainly in prostatic tissue and seminal fluid. PSA is also present in small quantities in the serum of normal men and is often elevated in the presence of prostate cancer and in other prostate disorders.

71834853

NP_001025218.1

NM_001030047.1

P07288

Protein Molecular Weight: 30 kDa

Androgen Receptor Signaling Pathway (198806); Coregulation Of Androgen Receptor Activity Pathway (138085); FOXA1 Transcription Factor Network Pathway (137979); Metabolism Of Proteins Pathway (106230); Pathways In Cancer (83105); Prostate Cancer Pathway (755440); Prostate Cancer Pathway (83111); Prostate Cancer Pathway (523); Regulation Of Androgen Receptor Activity Pathway (138027); Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway (105908)

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

PSA: Hydrolyzes semenogelin-1 thus leading to the liquefaction of the seminal coagulum. Forms heterodimer with SERPINA5. Inhibited by SERPINA5. Activity is strongly inhibited by Zn2+, 100 times more abundant in semen than in serum. This inhibition is relieved by exposure to semenogelins, which are avid zinc binders. Belongs to the peptidase S1 family. Kallikrein subfamily. Protein type: Secreted; EC 3.4.21.77; Secreted, signal peptide; Protease. Chromosomal Location of Human Ortholog: 19q13.41. Cellular Component: extracellular region; nucleus. Molecular Function: protein binding; serine-type peptidase activity; serine-type endopeptidase activity. Biological Process: negative regulation of angiogenesis; cellular protein metabolic process; proteolysis

0.1 mg

440 USD