protein

NATIVE HUMAN PREALBUMIN

MBS230219

1 mg

290 USD

Purified Protein

NATIVE HUMAN PREALBUMIN

PREALBUMIN

TRANSTHYRETIN, PALB

transthyretin; Transthyretin; transthyretin; ATTR; carpal tunnel syndrome 1; epididymis luminal protein 111; prealbumin, amyloidosis type I; thyroxine-binding prealbumin; transthyretin; ATTR; Prealbumin; TBPA

TTR; TTR; CTS; CTS1; PALB; TBPA; HEL111; HsT2651; PALB

TTHY_HUMAN

147

>96%SDS-PAGE confirms prealbumin as the major component. Under certain conditions dimer and monomer subunits can be seen. Cellulose acetate electrophoresis shows one band only with a higher electrophoretic mobility than albumin.

Purified protein from human serum - lyophilised.

Total protein concentration 1.0 mg/ml after reconstitution.

Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 12 months from date of reconstitution. Shipping: Ships with Dry Ice

ELISA (EIA)

Reconstitution: Reconstitute with 1 ml sterile PBS. Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution.

Buffer Solution: 0.02M Ammonium bicarbonate (NH 4 HCO 3 ). Target Species: Human. Presevative stabilizers: None present. Health and Safety Information: Donor material tested and found negative for HIV1 and 2 antibodies, HBsAg, HCV antibodies and HIV antigen P24. As no test can completely guarentee this material to be free of pathogens it should be handled as potentially infectious.

Native human prealbumin, also known as transthyretin, is a homotetrameric serum and cerebrospinal fluid protein which acts as a carrier for the thyroid hormone thyroxine. Each monomer is a 127 amino acid polypeptide. Prealbumin is synthesised principally in the liver and choroid plexus from where it is secreted into the serum and cerebrospinal fluid respectively.

4507725

NP_000362.1

NM_000371.3

P02766

60kDa

Amyloids Pathway (366238); Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Extracellular Matrix Organization Pathway (576262); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Non-integrin Membrane-ECM Interactions Pathway (833810); Retinoid Cycle Disease Events Pathway (771582); Retinoid Metabolism And Transport Pathway (187208); Signal Transduction Pathway (477114); The Canonical Retinoid Cycle In Rods (twilight Vision) Pathway (771585)

This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq, Jan 2009]

TTR: Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR). A hereditary generalized amyloidosis due to transthyretin amyloid deposition. Protein fibrils can form in different tissues leading to amyloid polyneuropathies, amyloidotic cardiomyopathy, carpal tunnel syndrome, systemic senile amyloidosis. The disease includes leptomeningeal amyloidosis that is characterized by primary involvement of the central nervous system. Neuropathologic examination shows amyloid in the walls of leptomeningeal vessels, in pia arachnoid, and subpial deposits. Some patients also develop vitreous amyloid deposition that leads to visual impairment (oculoleptomeningeal amyloidosis). Clinical features include seizures, stroke-like episodes, dementia, psychomotor deterioration, variable amyloid deposition in the vitreous humor. Defects in TTR are a cause of hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE). It is a condition characterized by elevation of total and free thyroxine in healthy, euthyroid persons without detectable binding protein abnormalities. Defects in TTR are a cause of carpal tunnel syndrome type 1 (CTS1). It is a condition characterized by entrapment of the median nerve within the carpal tunnel. Symptoms include burning pain and paresthesias involving the ventral surface of the hand and fingers which may radiate proximally. Impairment of sensation in the distribution of the median nerve and thenar muscle atrophy may occur. This condition may be associated with repetitive occupational trauma, wrist injuries, amyloid neuropathies, rheumatoid arthritis. Belongs to the transthyretin family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: extracellular space; protein complex; cytoplasm; extracellular region. Molecular Function: identical protein binding; protein binding; protein heterodimerization activity; hormone activity. Biological Process: phototransduction, visible light; extracellular matrix organization and biogenesis; transport; retinol metabolic process; retinoid metabolic process. Disease: Hyperthyroxinemia, Dystransthyretinemic; Carpal Tunnel Syndrome; Amyloidosis, Hereditary, Transthyretin-related

1 mg

290 USD