NATIVE HUMAN BETA 2 MICROGLOBULIN | MyBioSource MBS230191 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

NATIVE HUMAN BETA 2 MICROGLOBULIN

catalog :

MBS230191

quantity :

1 mg

price :

340 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS230191

products type :

Purified Protein

products full name :

NATIVE HUMAN BETA 2 MICROGLOBULIN

products short name :

BETA 2 MICROGLOBULIN

other names :

beta-2-microglobulin; Beta-2-microglobulin; beta-2-microglobulin; beta chain of MHC class I molecules; beta-2-microglobin; beta-2-microglobulin

other gene names :

B2M; B2M

uniprot entry name :

B2MG_HUMAN

sequence length :

119

purity :

>40% by SDS-PAGE

form :

Purified. Human beta-2 microglobulin - lyophilised

storage stability :

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the protein. Shelf Life: 12 months from date of reconstitution.

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Reconstitution: Reconstitute with 1.0ml sterile PBS . Care should be taken during reconstitution as the protein may appear as a film at the bottom of the vial. MyBioSource recommends that the vial is gently mixed after reconstitution. Preparation: Human beta-2 microglobulin was prepared from urine from patients with renal tubular proteinuria.

other info2 :

Buffer Solution: Ammonium bicarbonate. Target Species: Human

products description :

MBS230191, native beta-2 microglobulin is a component of MHC class I molecules, which are present on all nucleated cells. Levels of beta-2 microglobulin can be used to assess renal function in kidney transplant recipients. Also known as B2M, it has been suggested that this protein can be used as a prognostic marker for HIV infection.

ncbi gi num :

4757826

ncbi acc num :

NP_004039.1

ncbi gb acc num :

NM_004048.2

uniprot acc num :

P61769

ncbi mol weight :

Protein Molecular Weight: 12 kDa

ncbi pathways :

Adaptive Immune System Pathway (366160); Amyloids Pathway (366238); Antigen Presentation: Folding, Assembly And Peptide Loading Of Class I MHC Pathway (366163); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Antigen Processing-Cross Presentation Pathway (477122); Class I MHC Mediated Antigen Processing Presentation Pathway (366161); Cytokine Signaling In Immune System Pathway (366171); DAP12 Interactions Pathway (685549); DAP12 Signaling Pathway (685550)

ncbi summary :

This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. The encoded antimicrobial protein displays antibacterial activity in amniotic fluid. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Aug 2014]

uniprot summary :

B2M: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. Belongs to the beta-2-microglobulin family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 15q21.1. Cellular Component: Golgi membrane; Golgi apparatus; extracellular space; phagocytic vesicle membrane; focal adhesion; membrane; early endosome membrane; endoplasmic reticulum lumen; cytoplasm; plasma membrane; extracellular region; MHC class I protein complex; external side of plasma membrane. Molecular Function: identical protein binding; protein binding. Biological Process: response to drug; regulation of immune response; viral reproduction; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent; T cell differentiation in the thymus; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; regulation of defense response to virus by virus; retinal homeostasis; iron ion homeostasis; antigen processing and presentation of peptide antigen via MHC class I; response to cadmium ion; response to molecule of bacterial origin; innate immune response; antigen processing and presentation of exogenous peptide antigen via MHC class I; protein refolding; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Disease: Hypoproteinemia, Hypercatabolic

size1 :

1 mg

price1 :

340 USD

more info or order :

MyBioSource product webpage