SYNTHETIC ALPHA MELANOCYTE STIMULATING HORMONE | MyBioSource MBS230189 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

SYNTHETIC ALPHA MELANOCYTE STIMULATING HORMONE

catalog :

MBS230189

quantity :

0.5 mg

price :

190 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS230189

products type :

Purified Protein

products full name :

SYNTHETIC ALPHA MELANOCYTE STIMULATING HORMONE

products short name :

ALPHA MELANOCYTE STIMULATING HORMONE

products name syn :

ALPHA MSH

other names :

pro-opiomelanocortin preproprotein; Pro-opiomelanocortin; pro-opiomelanocortin; adrenocorticotropic hormone; adrenocorticotropin; alpha-MSH; alpha-melanocyte-stimulating hormone; beta-LPH; beta-MSH; beta-endorphin; beta-melanocyte-stimulating hormone; corticotropin-like intermediary peptide; corticotropin-lipotropin; gamma-LPH; gamma-MSH; lipotropin beta; lipotropin gamma; melanotropin alpha; melanotropin beta; melanotropin gamma; met-enkephalin; opiomelanocortin prepropeptide; pro-ACTH-endorphin; proopiomelanocortin preproprotein; proopiomelanocortin; Corticotropin-lipotropinCleaved into the following 11 chains:NPP; Melanotropin gammaAlternative name(s):Gamma-MSH

other gene names :

POMC; POMC; LPH; MSH; NPP; POC; ACTH; CLIP; POMC; ACTH; CLIP

uniprot entry name :

COLI_HUMAN

sequence length :

267

purity :

HPLC: >95%

form :

Purified. Purified synthetic peptide - liquid

concentration :

Total protein concentration 1 mg/ml

storage stability :

Store at -20 degree C only. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Shelf Life: 12 months from date of reconstitution.

tested application :

ELISA (EIA)

other info1 :

Preparation: Solid phase synthesis. Product Type: Purified Protein

other info2 :

Buffer Solution: Acetate salt. Preservative Stabilizers: See Buffer Solution

products description :

Synthetic alpha-melanocyte stimulating hormonePeptide sequence: Ac-SYSMEHFRWGKPV-NH2Alpha-MSH is a peptide hormone produced in the anterior pituitary gland involved in melanin production and deposition. It is also associated with the actions and production of proinflammatory cytokines such as TNF-a.

ncbi gi num :

4505949

ncbi acc num :

NP_000930.1

ncbi gb acc num :

NM_000939.2

uniprot acc num :

P01189

ncbi mol weight :

1665

ncbi pathways :

Adipocytokine Signaling Pathway (83093); Adipocytokine Signaling Pathway (505); Androgen Biosynthesis Pathway (106154); Biological Oxidations Pathway (105698); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Corticotropin-releasing Hormone Pathway (920957); Cytochrome P450 - Arranged By Substrate Type Pathway (105700); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Defective CYP11A1 Causes Adrenal Insufficiency, Congenital, With 46,XY Sex Reversal (AICSR) Pathway (1127640); Defective CYP11B1 Causes Adrenal Hyperplasia 4 (AH4) Pathway (1127641)

ncbi summary :

This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Nov 2014]

uniprot summary :

POMC: ACTH stimulates the adrenal glands to release cortisol. Defects in POMC may be associated with susceptibility to obesity (OBESITY). It is a condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat. Defects in POMC are the cause of pro-opiomelanocortinin deficiency (POMCD). Affected individuals present early-onset obesity, adrenal insufficiency and red hair. Belongs to the POMC family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 2p23.3. Cellular Component: extracellular space; peroxisomal matrix; cytoplasm; extracellular region; peroxisome; secretory granule. Molecular Function: type 3 melanocortin receptor binding; G-protein-coupled receptor binding; hormone activity; type 4 melanocortin receptor binding; receptor binding. Biological Process: generation of precursor metabolites and energy; cellular protein metabolic process; cell-cell signaling; neuropeptide signaling pathway; regulation of blood pressure; peptide hormone processing; regulation of appetite; positive regulation of transcription from RNA polymerase II promoter; negative regulation of tumor necrosis factor production; glucose homeostasis; signal transduction; cellular pigmentation. Disease: Obesity; Proopiomelanocortin Deficiency

size1 :

0.5 mg

price1 :

190 USD

more info or order :

MyBioSource product webpage