protein

SYNTHETIC HUMAN CHOLECYSTOKININ

MBS230104

0.1 mg

205 USD

Purified Protein

SYNTHETIC HUMAN CHOLECYSTOKININ

CHOLECYSTOKININ

cholecystokinin preproprotein; Cholecystokinin; cholecystokinin; cholecystokinin triacontatriapeptide; prepro-cholecystokinin; cholecystokinin; (1-49)-CCK58

CCK; CCK; CCK; CCK58; CCK39; CCK33; CCK25; CCK18; CCK12; CCK8; CCK7; CCK5

CCKN_HUMAN

115

DYMGWMDF

>97% by HPLC analysis

Purified. Purified synthetic peptide - lyophilised

Prior to reconstitution store at 4 degree C. After reconstitution store at -20 degree C. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the protein. Shelf Life: 6 months from date of despatch.

ELISA (EIA)

ELISA: Sufficient to coat up to 500 microtitre plate wells for simple ELISA, when used at 1 ug/ml.

Reconstitution: Reconstitute with sterile distilled water. This peptide is difficult to solubilise in water if the crystal is large. Solubility maybe helped by crushing the crystals prior to the addition of water. Preparation: Solid phase synthesis

Target Species: Human

Cholecystokinin (CCK) is a peptide hormone of the gastrointestinal system that is responsible for stimulating the digestion of fat and protein. It's synthesised by I-cells in the mucosal epithelium of the small intestine and secreted in the duodenum.

4502605

NP_000720.1

NM_000729.4

P06307

1063.3 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); G Alpha (q) Signalling Events Pathway (106043); GPCR Downstream Signaling Pathway (119548); GPCR Ligand Binding Pathway (161020); Gastrin-CREB Signalling Pathway Via PKC And MAPK (645295); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Peptide Ligand-binding Receptors Pathway (106358); Signal Transduction Pathway (477114)

Cholecystokinin is a brain/gut peptide. In the gut, it induces the release of pancreatic enzymes and the contraction of the gallbladder. In the brain, its physiologic role is unclear. The cholecystokinin pro-hormone is processed by endo- and exo-proteolytic cleavages. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]

CCK: This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion. Belongs to the gastrin/cholecystokinin family. Protein type: Secreted, signal peptide; Secreted; Hormone; Cell development/differentiation. Chromosomal Location of Human Ortholog: 3p22.1. Cellular Component: axon hillock; extracellular space; axon; dendrite; extracellular region; terminal button; perikaryon. Molecular Function: neuropeptide hormone activity; protein binding; hormone activity. Biological Process: caspase activation; release of cytochrome c from mitochondria; behavioral fear response; eating behavior; neuron migration; signal transduction; negative regulation of appetite; positive regulation of protein oligomerization; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of mitochondrial depolarization; axonogenesis; positive regulation of cell proliferation; protein kinase C activation; regulation of sensory perception of pain

0.1 mg

205 USD