antibody

RABBIT ANTI HUMAN CD234 (N-TERMINAL)

MBS224136

0.1 mg

355 USD

polyclonal

rabbit

nonconjugated

Antibody

RABBIT ANTI HUMAN CD234 (N-TERMINAL)

CD234

atypical chemokine receptor 1 isoform a; Atypical chemokine receptor 1; atypical chemokine receptor 1; Duffy blood group antigen; Duffy blood group, atypical chemokine receptor; Duffy blood group, chemokine receptor; Fy glycoprotein; glycoprotein D; plasmodium vivax receptor; atypical chemokine receptor 1 (Duffy blood group); Duffy antigen/chemokine receptor; Fy glycoprotein; GpFy; Glycoprotein D; Plasmodium vivax receptor; CD_antigen: CD234

CD234

ACKR1; ACKR1; FY; Dfy; GPD; DARC; GpFy; CCBP1; CD234; WBCQ1; DARC; FY; GPD; GpFy

ACKR1_HUMAN

Polyclonal

IgG

Rabbit

338

CD234 (C-Terminal). This item detects CD234, also known as DARC, a multi-pass membrane protein belonging to the G protein coupled Duffy family. CD234 is a non-specific receptor for a number of cytokines including IL-8, GRO, RANTES, MCP-1 and TARC. CD234 also functions as the receptor for the malaria parasites Plasmodium vivax and P. knowlesi. CD234 is also responsible for the Duffy blood group system where a substitution at position 42 of either Gly-42 or Asp-42 results in Fy(A) or Fy(B). CD234 is present in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along post capillary venules throughout the body, except in the adult liver. Erythroid cells and post capillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium. It has been demonstrated that CD234 exists in multiple isoforms.

Purified. Purified IgG - liquid

1.0mg/ml

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

Immunohistology Paraffin*, Western Blot (WB)

Western Blot: This item detects a band of approximately 16kDa in PC-3 cell lysate. Immunohistology - Paraffin: Maximum Dilution: 5.0ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. . Western Blotting: Minimum Dilution: 1.0; Maximum Dilution: 2.0ug/ml

Perservative Stabilisers: 0.02% Sodium Azide (NaN3)

Immunogen: A peptide corresponding to a 18 amino acid sequence from near the amino terminus of Human CD234. Histology Positive Control Tissue: Human brain tissue. Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antisera to Human CD234 were raised by repeated immunisation of rabbits with highly purified antigen. Purified IgG prepared from whole serum by affinity chromatography. Target Species: Human

MBS224136 detects CD234, also known as DARC, a multi-pass membrane protein belonging to the G protein coupled Duffy family. CD234 is a non-specific receptor for a number of cytokines including IL-8, GRO, RANTES, MCP-1 and TARC. CD234 also functions as the receptor for the malaria parasites Plasmodium vivax and P. knowlesi. CD234 is also responsible for the Duffy blood group system where a substitution at position 42 of either Gly-42 or Asp-42 results in Fy(A) or Fy(B). CD234 is present in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed along post capillary venules throughout the body, except in the adult liver. Erythroid cells and post capillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in postcapillary venule endothelium. It has been demonstrated that CD234 exists in multiple isoforms.

171846251

NP_001116423.1

NM_001122951.2

Q16570

35,678 Da

Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway (1127664); Disease Pathway (530764); GPCR Ligand Binding Pathway (161020); GPCRs, Other Pathway (198765); Malaria Pathway (152665); Malaria Pathway (152657); Metabolic Disorders Of Biological Oxidation Enzymes Pathway (1127637); Peptide GPCRs Pathway (198897); Peptide Ligand-binding Receptors Pathway (106358)

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DARC: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi. Belongs to the G-protein coupled receptor Duffy family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, Duffy family. Chromosomal Location of Human Ortholog: 1q21-q22. Cellular Component: recycling endosome; early endosome; integral to membrane; plasma membrane. Molecular Function: G-protein coupled receptor activity; transmembrane receptor activity; C-C chemokine binding; receptor activity. Biological Process: G-protein coupled receptor protein signaling pathway; defense response; inflammatory response; regulation of chemokine production. Disease: White Blood Cell Count Quantitative Trait Locus 1; Blood Group, Duffy System; Malaria, Susceptibility To

0.1 mg

355 USD