RABBIT ANTI SIGIRR (C-TERMINAL) | MyBioSource MBS224080 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

RABBIT ANTI SIGIRR (C-TERMINAL)

catalog :

MBS224080

quantity :

0.1 mg

price :

355 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS224080

products type :

Antibody

products full name :

RABBIT ANTI SIGIRR (C-TERMINAL)

products short name :

SIGIRR

other names :

single Ig IL-1-related receptor; Single Ig IL-1-related receptor; single Ig IL-1-related receptor; single Ig IL-1R-related molecule; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; toll/interleukin-1 receptor 8; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; Single Ig IL-1R-related molecule; Single immunoglobulin domain-containing IL1R-related protein; Toll/interleukin-1 receptor 8; TIR8

products gene name :

SIGIRR

other gene names :

SIGIRR; SIGIRR; TIR8; TIR8

uniprot entry name :

SIGIR_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Rabbit

reactivity :

Human

sequence length :

410

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 1.0mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

Immunohistology Frozen, Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 43kDa in A549 cell lysate. Immunohistology - Frozen: Maximum Dilution: 10ug/ml. Western Blotting: Minimum Dilution: 0.5; Maximum Dilution: 1ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide (NaN3)

other info2 :

Buffer Solution: Phosphate buffered saline. Antiserum Preparation: Antiserum to SIGIRR (CT) was raised by repeated immunisation of with highly purified antigen. Purified IgG was prepared from whole serum by immunoaffinity chromatography. Target Species: Mouse

products description :

Rabbit anti SIGIRR (C-terminal) antibody recognises the Single Ig IL-1-related receptor (SIGIRR), a member of the Toll-like receptor-interleukin 1 receptor superfamily, defined by an intracellular Toll-IL-1R (TIR) domain. SIGIRR acts as a negative regulator of the Toll-like and IL-1R receptor signalling pathways. It interacts with TLR4, TLR5, TLR9 and IL-1R through the extracellular Ig domain, or the intracellular TIR domain. The Ig domain interferes with the heterodimerization of IL-1R while the intracellular TIR domain inhibits both IL-1 and LPS signalling by attenuating the recruitment of receptor-proximal signalling components to TLR4. SIGIRR is expressed in kidney, colon, small intestine, lung, spleen and liver. It is not expressed in brain and muscle.

ncbi gi num :

205277449

ncbi acc num :

NP_001128525.1

ncbi gb acc num :

NM_001135053.1

ncbi mol weight :

55,271 Da

ncbi pathways :

Activated TLR4 Signalling Pathway (106400); Immune System Pathway (106386); Innate Immune System Pathway (106387); MyD88:Mal Cascade Initiated On Plasma Membrane Pathway (106390); Toll Like Receptor 2 (TLR2) Cascade Pathway (106402); Toll Like Receptor 4 (TLR4) Cascade Pathway (106398); Toll Like Receptor TLR1:TLR2 Cascade Pathway (106403); Toll Like Receptor TLR6:TLR2 Cascade Pathway (106404); Toll-Like Receptors Cascades Pathway (106388)

uniprot summary :

SIGIRR: Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP. Belongs to the interleukin-1 receptor family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: membrane; integral to membrane. Molecular Function: protein binding. Biological Process: negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of transcription factor activity; acute-phase response; negative regulation of cytokine and chemokine mediated signaling pathway; signal transduction; negative regulation of chemokine biosynthetic process

size1 :

0.1 mg

price1 :

355 USD

more info or order :

MyBioSource product webpage