GOAT ANTI HUMAN RAB8A (C-TERMINAL) | MyBioSource MBS224069 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

GOAT ANTI HUMAN RAB8A (C-TERMINAL)

catalog :

MBS224069

quantity :

0.1 mg

price :

515 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

human, dog, cow

application :

western blot, ELISA, enzyme immunoassay

product information

catalog number :

MBS224069

products type :

Antibody

products full name :

GOAT ANTI HUMAN RAB8A (C-TERMINAL)

products short name :

RAB8A

other names :

ras-related protein Rab-8A; Ras-related protein Rab-8A; ras-related protein Rab-8A; mel transforming oncogene (RAB8 homolog); mel transforming oncogene (derived from cell line NK14); mel transforming oncogene (derived from cell line NK14)- RAB8 homolog; oncogene c-mel; ras-associated protein RAB8; RAB8A, member RAS oncogene family; Oncogene c-mel

products gene name :

RAB8A

other gene names :

RAB8A; RAB8A; MEL; RAB8; MEL; RAB8

uniprot entry name :

RAB8A_HUMAN

clonality :

Polyclonal

isotype :

IgG

host :

Goat

reactivity :

Bovine (Expected from Sequence), Dog (Expected from Sequence)

sequence length :

207

form :

Purified. Purified IgG - liquid

concentration :

IgG concentration 0.5mg/ml

storage stability :

Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use. Shelf Life: 18 months from date of despatch.

tested application :

ELISA (EIA), Western Blot (WB)

app notes :

Western Blot: This item detects a band of approximately 25kDa in human cerebellum and kidney cell lysates. ELISA: Maximum Dilution: 1/32000. Western Blotting: Minimum Dilution: 0.1; Maximum Dilution: 0.3ug/ml

other info1 :

Perservative Stabilisers: 0.02% Sodium Azide (NaN3). 0.5% Bovine Serum Albumin

other info2 :

Buffer Solution: TRIS buffered saline. Antiserum Preparation: Antiserum to human RAB8A (CT) was raised by repeated immunisation of goats with highly purified antigen. Purified IgG was prepared by affinity chromatography. Target Species: Human

products description :

Goat anti Human RAB8A antibody recognizes an epitope within the C-terminal (CT) region of the human RAS superfamily member Rab8a (Ras-related protein Rab-8A), otherwise known as oncogene c-mel, Rab8A is a small monomeric GTP/GDP-binding protein with a predicted molecular weight of ~24kDa which may play a role in vesicular trafficking and neurotransmitter release. The Rab family of proteins, originally described as Ras-like proteins in brain are the largest group of GTPases within the Ras superfamily with 61 protein members identified. Rab family members are involved in the regulation of intracellular vesicular transport and movement of proteins between endocytic and secretory organelles (Wennerberg et al. 2005). Rab8A is involved in vesicular traffic between the trans golgi network and the basoleteral aspect of the plasma membrane (Huber et al. 1993). Goat anti human Rab8a antibody has been successfully used for the detection of Rab8a in human intestinal epithelial cells using Western blotting (Vacca et al. 2014).

ncbi gi num :

16933567

ncbi acc num :

NP_005361.2

ncbi gb acc num :

NM_005370.4

uniprot acc num :

P61006

ncbi mol weight :

23,564 Da

ncbi pathways :

AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Anchoring Of The Basal Body To The Plasma Membrane Pathway 1127503!!Assembly Of The Primary Cilium Pathway 1127502!!Cargo Trafficking To The Periciliary Membrane Pathway 1127504!!Cell Cycle Pathway 530733!!Cell Cycle, Mitotic Pathway 105765!!G2/M Transition Pathway 105801!!Membrane Trafficking Pathway 106160!!Mitotic G2-G2/M Phases Pathway 160942

ncbi summary :

The protein encoded by this gene is a member of the RAS superfamily which are small GTP/GDP-binding proteins with an average size of 200 amino acids. The RAS-related proteins of the RAB/YPT family may play a role in the transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane. This protein shares 97%, 96%, and 51% similarity with the dog RAB8, mouse MEL, and mouse YPT1 proteins, respectively and contains the 4 GTP/GDP-binding sites that are present in all the RAS proteins. The putative effector-binding site of this protein is similar to that of the RAB/YPT proteins. However, this protein contains a C-terminal CAAX motif that is characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins. Although this gene was isolated as a transforming gene from a melanoma cell line, no linkage between MEL and malignant melanoma has been demonstrable. This oncogene is located 800 kb distal to MY09B on chromosome 19p13.1. [provided by RefSeq, Jul 2008]

size :

0.1 mg

price :

515 USD